ArticleProceedings of the National Academy of Sciences of the United States of America2017
Ecdysone signaling underlies the pea aphid transgenerational wing polyphenism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 153 citations in OpenAlex.
- Delivery, Persistence, and Functional Response of dsRNA in Acyrthosiphon pisum: Progress and Remaining Barriers.Archives of insect biochemistry and physiology · 2026Article
- An Integrated Morphometric-Molecular Framework for Characterization of Developmental Stages in the Safflower AphidInternational journal of molecular sciences · 2026Article
- Reduction of Buchnera with rifampicin impairs the density-dependent induction of winged morph in pea aphid.Insect science · 2026Article
- The ABCG23-4 gene regulates wing polyphenism and dispersal potential in the bird cherry-oat aphid under high-density stress.Pest management science · 2026Article
- Aphid wing plasticity: hormonal and epigenetic control mechanisms.Current opinion in insect science · 2026Review
- Transcriptomic and DNA Methylation Profiles of Alternative Aphid Morphs and Genotypes.Ecology and evolution · 2026Article
- Gene Expression ofInternational journal of molecular sciences · 2026Article
- The Stochastic Pacemaker: Cumulative Behavioral Noise Drives Morphological Plasticity in Pea Aphids.bioRxiv : the preprint server for biology · 2026Article
- TheFrontiers in physiology · 2026Article
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- The maternal vGluT2 and embryonic mGluR3 signaling relay system controls offspring wing dimorphism in pea aphid.iScience · 2025Article
- Comprehensive full-Length transcriptomic resource for wing dimorphism in English green aphid, Sitobion avenae.Scientific data · 2025Article
- Oocyte mitochondria link maternal environment to offspring phenotype.bioRxiv : the preprint server for biology · 2025Article
- A-to-I RNA editing ofeLife · 2025Article
- Wingless strain created using binary transgenic CRISPR/Cas9 alleviates concerns about mass rearing of Hermetia illucens.Communications biology · 2024Article
- Review
- Neuropeptide Bursicon and its receptor-mediated the transition from summer-form to winter-form ofeLife · 2024Article
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- Insect Flight: State of the Field and Future Directions.Integrative and comparative biology · 2024Article
- Wing Plasticity Is Associated with Growth and Energy Metabolism in Two Color Morphs of the Pea Aphid.Insects · 2024Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The wing polyphenism of pea aphids is a compelling laboratory model with which to study the molecular mechanisms underlying phenotypic plasticity. In this polyphenism, environmental stressors such as high aphid density cause asexual, viviparous adult female aphids to alter the developmental fate of their embryos from wingless to winged morphs. This polyphenism is transgenerational, in that the pea aphid mother experiences the environmental signals, but it is her offspring that are affected. Previous research suggested that the steroid hormone ecdysone may play a role in this polyphenism. Here, we analyzed ecdysone-related gene expression patterns and found that they were consistent with a down-regulation of the ecdysone pathway being involved in the production of winged offspring. We therefore predicted that reduced ecdysone signaling would result in more winged offspring. Experimental injections of ecdysone or its analog resulted in a decreased production of winged offspring. Conversely, interfering with ecdysone signaling using an ecdysone receptor antagonist or knocking down the ecdysone receptor gene with RNAi resulted in an increased production of winged offspring. Our results are therefore consistent with the idea that ecdysone plays a causative role in the regulation of the proportion of winged offspring produced in response to crowding in this polyphenism. Our results also show that an environmentally regulated maternal hormone can mediate phenotype production in the next generation, as well as provide significant insight into the molecular mechanisms underlying the functioning of transgenerational phenotypic plasticity.
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