Evidence map›Paper›PMID 28115552›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2017

Xenin Augments Duodenal Anion Secretion via Activation of Afferent Neural Pathways.

Izumi Kaji, Yasutada Akiba, Ikuo Kato, Koji Maruta, Atsukazu Kuwahara, Jonathan D Kaunitz

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Xenin-25 improves indomethacin-induced acute gastric injury in rats.Pflugers Archiv : European journal of physiology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Luminal chemosensing in the gastroduodenal mucosa.Current opinion in gastroenterology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Izumi KajiGreater Los Angeles Veterans Affairs Healthcare System Los Angeles, California (I.K., Y.A., J.D.K.); Departments of Medicine (I.K., Y.A., K.M., J.D.K.) and Surgery (J.D.K.), David Geffen School of Medicine at UCLA, Los Angeles, California; Department of Medical Biochemistry, Kobe Pharmaceutical University, Kobe, Kobe, Japan (I.K.); and Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Japan (A.K.).
Yasutada AkibaGreater Los Angeles Veterans Affairs Healthcare System Los Angeles, California (I.K., Y.A., J.D.K.); Departments of Medicine (I.K., Y.A., K.M., J.D.K.) and Surgery (J.D.K.), David Geffen School of Medicine at UCLA, Los Angeles, California; Department of Medical Biochemistry, Kobe Pharmaceutical University, Kobe, Kobe, Japan (I.K.); and Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Japan (A.K.).
Ikuo KatoGreater Los Angeles Veterans Affairs Healthcare System Los Angeles, California (I.K., Y.A., J.D.K.); Departments of Medicine (I.K., Y.A., K.M., J.D.K.) and Surgery (J.D.K.), David Geffen School of Medicine at UCLA, Los Angeles, California; Department of Medical Biochemistry, Kobe Pharmaceutical University, Kobe, Kobe, Japan (I.K.); and Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Japan (A.K.).
Koji MarutaGreater Los Angeles Veterans Affairs Healthcare System Los Angeles, California (I.K., Y.A., J.D.K.); Departments of Medicine (I.K., Y.A., K.M., J.D.K.) and Surgery (J.D.K.), David Geffen School of Medicine at UCLA, Los Angeles, California; Department of Medical Biochemistry, Kobe Pharmaceutical University, Kobe, Kobe, Japan (I.K.); and Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Japan (A.K.).
Atsukazu KuwaharaGreater Los Angeles Veterans Affairs Healthcare System Los Angeles, California (I.K., Y.A., J.D.K.); Departments of Medicine (I.K., Y.A., K.M., J.D.K.) and Surgery (J.D.K.), David Geffen School of Medicine at UCLA, Los Angeles, California; Department of Medical Biochemistry, Kobe Pharmaceutical University, Kobe, Kobe, Japan (I.K.); and Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Japan (A.K.).
Jonathan D KaunitzGreater Los Angeles Veterans Affairs Healthcare System Los Angeles, California (I.K., Y.A., J.D.K.); Departments of Medicine (I.K., Y.A., K.M., J.D.K.) and Surgery (J.D.K.), David Geffen School of Medicine at UCLA, Los Angeles, California; Department of Medical Biochemistry, Kobe Pharmaceutical University, Kobe, Kobe, Japan (I.K.); and Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Japan (A.K.) jake@ucla.edu.
University of California, Los Angeles · USKobe Pharmaceutical University · JPUniversity of Shizuoka · JPVA Greater Los Angeles Healthcare System · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Duodenal Muscosal Defense MechanismsR01DK054221 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAUNITZ, JONATHAN D. · 1999 to 2016
$4.4M
Luminal Factors Affecting Duodenal Protection and ChemosensingI01BX001245 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI KAUNITZ, JONATHAN D. · 2012 to 2025
–
BLRD VA I01 BX001245NIDDK NIH HHS P30 DK041301NIDDK NIH HHS R01 DK054221
6 · The paper itself

Abstract

Xenin-25, a neurotensin (NT)-related anorexigenic gut hormone generated mostly in the duodenal mucosa, is believed to increase the rate of duodenal ion secretion, because xenin-induced diarrhea is not present after Roux-en-Y gastric bypass surgery. Because the local effects of xenin on duodenal ion secretion have remained uninvestigated, we thus examined the neural pathways underlying xenin-induced duodenal anion secretion. Intravenous infusion of xenin-8, a bioactive C-terminal fragment of xenin-25, dose dependently increased the rate of duodenal HCO

Indexed as

Afferent PathwaysAnimalsDose-Response Relationship, DrugDuodenumGastrointestinal HormonesIntestinal MucosaMaleNeural PathwaysNeurons, AfferentNeurotensinOrgan Culture TechniquesRatsRats, Sprague-DawleyGastrointestinal HormonesNeurotensinxenin 25

Identifiers

PMID28115552
PMCPMC5363776
OpenAlexW2580597134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.