ArticleJournal of immunology (Baltimore, Md. : 1950)2017
IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice.
Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- IL-4 rs2243250 polymorphism associated with susceptibility to allergic rhinitis: a meta-analysis.Bioscience reports · 2021Pooled it
- Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program.Immunity · 2025Article
- T follicular regulatory cells in food allergy promote IgE via IL-4.JCI insight · 2024Article
- Control of germinal center B cell survival and IgE production by an adaptor molecule containing PH and SH2 domains, Aps/Sh2b2.Scientific reports · 2024Article
- B cell receptor ligation induces IgE plasma cell elimination.The Journal of experimental medicine · 2023Article
- How an Immune-Factor-Based Formulation of Micro-Immunotherapy Could Interfere with the Physiological Processes Involved in the Atopic March.International journal of molecular sciences · 2023Review
- Chitinase-3-like 1 regulates TFrontiers in immunology · 2023Article
- Development of allergen-specific IgE in a food-allergy model requires precisely timed B cell stimulation and is inhibited by Fgl2.Cell reports · 2022Article
- Features of B Cell Responses Relevant to Allergic Disease.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Fasting impairs type 2 helper T cell infiltration in the lung of an eosinophilic asthma mouse model.FEBS open bio · 2021Article
- Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway.Journal of translational medicine · 2020Article
- IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells.The Journal of experimental medicine · 2020Article
- Luteolin Attenuates Allergic Nasal Inflammation via Inhibition of Interleukin-4 in an Allergic Rhinitis Mouse Model and Peripheral Blood From Human Subjects With Allergic Rhinitis.Frontiers in pharmacology · 2020Article
- Combined administration of anti-IL-13 and anti-IL-17A at individually sub-therapeutic doses limits asthma-like symptoms in a mouse model of Th2/Th17 high asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Article
- IL-4 Is a Key Requirement for IL-4- and IL-4/IL-13-Expressing CD4 Th2 Subsets in Lung and Skin.Frontiers in immunology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Polymorphisms in genes involved in IL-4 responses segregate with allergic disease risk and correlate with IgE levels in humans, and IL-4 promotes IgE and IgG1 Ab production against allergens in mice. We report that mice with only one intact
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.