ArticleThe Journal of biological chemistry2017
The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required for Normal Levels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory.
Open access · hybridAbstract read
In one paragraph
Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Genome-wide association study reveals acute mountain sickness susceptibility in Chinese population.Molecular genetics and genomics : MGG · 2026Article
- Nicotine-induced conditioned place preference involves dynamic changes in DNA methylation and hydroxymethylation in the zebrafish brain.Frontiers in cell and developmental biology · 2026Article
- Curcuminoids Activate TET Enzymes and Increase DNA Hydroxymethylation and Active Demethylation in Leukemia Cells.International journal of molecular sciences · 2025Article
- 5-Hydroxymethylcytosine: a key epigenetic mark in cancer and chemotherapy response.Epigenetics & chromatin · 2025Review
- Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes.Genome medicine · 2025Article
- A ternary-code DNA methylome atlas of mouse tissues.Genome biology · 2025Article
- UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells.Nature communications · 2025Article
- DNA Methylation in Long-Term Memory.Physiology (Bethesda, Md.) · 2025Review
- Genomic and ancestral variations linked to the development of post-acute sequelae of SARS-CoV-2 infection in Indian populations.Frontiers in genetics · 2025Article
- E3 Ubiquitin LigaseInternational journal of molecular sciences · 2024Article
- Impaired Repopulating Ability ofGenes · 2023Article
- Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index.Science advances · 2022Article
- Mechanisms that regulate the activities of TET proteins.Cellular and molecular life sciences : CMLS · 2022Review
- UHRF2 regulates cell cycle, epigenetics and gene expression to control the timing of retinal progenitor and ganglion cell differentiation.Development (Cambridge, England) · 2022Article
- Genome-wide 5-hydroxymethylcytosine (5hmC) reassigned in Pten-depleted mESCs along neural differentiation.Frontiers in cell and developmental biology · 2022Article
- The UHRF protein family in epigenetics, development, and carcinogenesis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2022Review
- TETology: Epigenetic Mastermind in Action.Applied biochemistry and biotechnology · 2021Review
- Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro-myelinating genes.Journal of neurochemistry · 2021Article
- Ten-eleven translocation proteins and their role beyond DNA demethylation - what we can learn from the fly.Epigenetics · 2020Review
- TET-Mediated Epigenetic Regulation in Immune Cell Development and Disease.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 6 institutions in 3 countries.
Ruoyu ChenFrom the Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Qiao ZhangFrom the Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Xiaoya DuanFrom the Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Philippe Yorkthe Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030.
Guo-Dong Chenthe Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China.
Pengcheng Yinthe Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.
Haijun ZhuFrom the Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Meichen Xuthe Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.
Peilin ChenFrom the Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Qihan WuFrom the Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Dali LiFrom the Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Jacques Samarutthe Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS UMR5242, Ecole Normale Supérieure de Lyon, Lyon 69007, France, and.
Guoliang Xuthe Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China.
Pumin Zhangthe Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030.
Xiaohua Caothe Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.
Jiwen LiFrom the Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China, jwli@bio.ecnu.edu.cn.
Jiemin WongFrom the Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China, jmweng@bio.ecnu.edu.cn.
East China Normal University · CNBaylor College of Medicine · USCenter for Excellence in Molecular Cell Science · CNChinese Academy of Sciences · CNÉcole Normale Supérieure de Lyon · FRSun Yat-sen University Cancer Center · CN
Funding
Spindle Assembly Checkpoint, Chromosome Stability, and CancerR01CA122623 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ZHANG, PUMIN · 2008 to 2016
$2.8MThe Function of Cdc14B in DNA Damage Repair and TumorigenesisR01CA116097 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ZHANG, PUMIN · 2006 to 2015
$2.6MGFP Genes Involved in Kidney DevelopmentU01DK070214 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI ZHANG, PUMIN · 2005 to 2009
$1.3MNCI NIH HHS R01 CA116097NCI NIH HHS R01 CA122623NIDDK NIH HHS U01 DK070214
Abstract
UHRF2 has been implicated as a novel regulator for both DNA methylation (5mC) and hydroxymethylation (5hmC), but its physiological function and role in DNA methylation/hydroxymethylation are unknown. Here we show that in mice, UHRF2 is more abundantly expressed in the brain and a few other tissues.
Indexed as
DNA MethylationSpatial Learning5-MethylcytosineAnimalsBrainBrain ChemistryCell LineFemaleHumansLocomotionMaleMemoryMiceMice, KnockoutUbiquitin-Protein Ligases5-hydroxymethylcytosine5-MethylcytosineUbiquitin-Protein LigasesUHRF2 protein, mousedioxygenaseDNA demethylationDNA methylationepigeneticsmouse geneticsneurobiologyprotein-DNA interaction
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.