Evidence map›Paper›PMID 28115520›Full record

ArticleThe Journal of biological chemistry2017

Cellular Uptake and Delivery of Myeloperoxidase to Lysosomes Promote Lipofuscin Degradation and Lysosomal Stress in Retinal Cells.

Gouri Yogalingam, Amanda R Lee, Donald S Mackenzie, Travis J Maures, Agnes Rafalko, Heather Prill, Geoffrey Y Berguig, Chuck Hague, Terri Christianson, Sean M Bell and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Neutrophils in Ocular Diseases.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Lysosomal Stress Response (LSR): Physiological Importance and Pathological Relevance.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Oxidative stress in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019
    Review
  15. Oral Health Status of Patients with Lysosomal Storage Diseases in Poland.International journal of environmental research and public health · 2017
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Gouri YogalingamFrom the Department of Research, BioMarin Pharmaceutical, Inc., San Rafael, California, 94901 gyogalingam@bmrn.com.
Amanda R LeeFrom the Department of Research, BioMarin Pharmaceutical, Inc., San Rafael, California, 94901.
Donald S MackenzieFrom the Department of Research, BioMarin Pharmaceutical, Inc., San Rafael, California, 94901.
Travis J MauresFrom the Department of Research, BioMarin Pharmaceutical, Inc., San Rafael, California, 94901.
Agnes RafalkoFrom the Department of Research, BioMarin Pharmaceutical, Inc., San Rafael, California, 94901.
Heather PrillFrom the Department of Research, BioMarin Pharmaceutical, Inc., San Rafael, California, 94901.
Geoffrey Y BerguigFrom the Department of Research, BioMarin Pharmaceutical, Inc., San Rafael, California, 94901.
Chuck HagueFrom the Department of Research, BioMarin Pharmaceutical, Inc., San Rafael, California, 94901.
Terri ChristiansonFrom the Department of Research, BioMarin Pharmaceutical, Inc., San Rafael, California, 94901.
Sean M BellFrom the Department of Research, BioMarin Pharmaceutical, Inc., San Rafael, California, 94901.
Jonathan H LeBowitzFrom the Department of Research, BioMarin Pharmaceutical, Inc., San Rafael, California, 94901.
BioMarin (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophil myeloperoxidase (MPO) catalyzes the H

Indexed as

Stress, PhysiologicalCells, CulturedHumansLipofuscinLysosomesPeroxidaseReceptor, IGF Type 2Retinal Pigment Epitheliumcation-dependent mannose-6-phosphate receptorLipofuscinPeroxidaseReceptor, IGF Type 2ABC transporterlysosomal storage diseaselysosomemannose 6-phosphate (M6P)myeloperoxidaseretinaretinal degeneration

Identifiers

PMID28115520
PMCPMC5354499
OpenAlexW2582465198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.