ArticleHypertension (Dallas, Tex. : 1979)2017
Ablation of Interferon Regulatory Factor 3 Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice.
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Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Interferon Regulatory Factors as Potential Therapeutic Targets in Cardiovascular Disease: Focusing on Vascular Inflammation.International journal of molecular sciences · 2026Review
- Emerging roles of the cGAS/STING pathway in cardiovascular diseases.The Journal of clinical investigation · 2026Review
- Article
- The role of interferon regulatory factors in atherosclerosis: from cell type-specific mechanisms to therapeutic strategies.Frontiers in cell and developmental biology · 2026Review
- Research progress on the mechanisms of cGAS-STING signaling in immune cell infiltration associated with vascular remodeling.Journal of translational medicine · 2025Review
- The Role and Therapeutic Potential of the cGAS-STING Signaling Pathway in Alzheimer's Disease.Brain and behavior · 2025Review
- Interplay Between KLF4, STAT, IRF, and NF-κB in VSMC and Macrophage Plasticity During Vascular Inflammation and Atherosclerosis.International journal of molecular sciences · 2025Review
- Effects of Dexamethasone and Tacrolimus on Mesenchymal Stem Cell Characteristics and Gene Expression.International journal of stem cells · 2025Article
- The Role of Ubiquitination on Macrophages in Cardiovascular Diseases and Targeted Treatment.International journal of molecular sciences · 2025Review
- Identification and validation of diagnostic markers of atherosclerosis progression via bioinformatics strategies.PloS one · 2025Article
- Integrative multi-omics analysis of IFNγ-induced macrophages and atherosclerotic plaques reveals macrophage-dependent STAT1-driven transcription in atherosclerosis.Frontiers in immunology · 2025Article
- The role of interferon regulatory factors in atherosclerosis.Frontiers in cardiovascular medicine · 2025Review
- The multiple roles of interferon regulatory factor family in health and disease.Signal transduction and targeted therapy · 2024Review
- Identification of ALEKSIN as a novel multi-IRF inhibitor of IRF- and STAT-mediated transcription in vascular inflammation and atherosclerosis.Frontiers in pharmacology · 2024Article
- Unraveling the cGAS/STING signaling mechanism: impact on glycerolipid metabolism and diseases.Frontiers in medicine · 2024Review
- The Role of cGAS-STING Signalling in Metabolic Diseases: from Signalling Networks to Targeted Intervention.International journal of biological sciences · 2024Review
- Review
- cGAS-STING Pathway Performance in the Vulnerable Atherosclerotic Plaque.Aging and disease · 2022Article
- Ginsenoside Rb3 attenuates skin flap ischemia-reperfusion damage by inhibiting STING-IRF3 signaling.Journal of molecular histology · 2022Article
- Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases.Journal of atherosclerosis and thrombosis · 2022Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Hui LiuFrom the Department of Cardiology, Renmin Hospital of Wuhan University, China (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li); and The Institute of Model Animals (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Medical Research Institute, School of Medicine (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Collaborative Innovation Center of Model Animal (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Cardiovascular Research Institute (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), and College of Life Science (Z.H.), Wuhan University, China.
Wen-Lin ChengFrom the Department of Cardiology, Renmin Hospital of Wuhan University, China (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li); and The Institute of Model Animals (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Medical Research Institute, School of Medicine (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Collaborative Innovation Center of Model Animal (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Cardiovascular Research Institute (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), and College of Life Science (Z.H.), Wuhan University, China.
Xi JiangFrom the Department of Cardiology, Renmin Hospital of Wuhan University, China (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li); and The Institute of Model Animals (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Medical Research Institute, School of Medicine (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Collaborative Innovation Center of Model Animal (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Cardiovascular Research Institute (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), and College of Life Science (Z.H.), Wuhan University, China.
Pi-Xiao WangFrom the Department of Cardiology, Renmin Hospital of Wuhan University, China (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li); and The Institute of Model Animals (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Medical Research Institute, School of Medicine (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Collaborative Innovation Center of Model Animal (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Cardiovascular Research Institute (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), and College of Life Science (Z.H.), Wuhan University, China.
Chun FangFrom the Department of Cardiology, Renmin Hospital of Wuhan University, China (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li); and The Institute of Model Animals (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Medical Research Institute, School of Medicine (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Collaborative Innovation Center of Model Animal (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Cardiovascular Research Institute (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), and College of Life Science (Z.H.), Wuhan University, China.
Xue-Yong ZhuFrom the Department of Cardiology, Renmin Hospital of Wuhan University, China (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li); and The Institute of Model Animals (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Medical Research Institute, School of Medicine (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Collaborative Innovation Center of Model Animal (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Cardiovascular Research Institute (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), and College of Life Science (Z.H.), Wuhan University, China.
Zan HuangFrom the Department of Cardiology, Renmin Hospital of Wuhan University, China (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li); and The Institute of Model Animals (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Medical Research Institute, School of Medicine (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Collaborative Innovation Center of Model Animal (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Cardiovascular Research Institute (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), and College of Life Science (Z.H.), Wuhan University, China.
Zhi-Gang SheFrom the Department of Cardiology, Renmin Hospital of Wuhan University, China (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li); and The Institute of Model Animals (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Medical Research Institute, School of Medicine (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Collaborative Innovation Center of Model Animal (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Cardiovascular Research Institute (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), and College of Life Science (Z.H.), Wuhan University, China.
Hongliang LiFrom the Department of Cardiology, Renmin Hospital of Wuhan University, China (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li); and The Institute of Model Animals (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Medical Research Institute, School of Medicine (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Collaborative Innovation Center of Model Animal (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Cardiovascular Research Institute (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), and College of Life Science (Z.H.), Wuhan University, China. lihl@whu.edu.cn.
Renmin Hospital of Wuhan University · CNWuhan University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
The secretion of adhesion molecules by endothelial cells, as well as the subsequent infiltration of macrophages, determines the initiation and progression of atherosclerosis. Accumulating evidence suggests that IRF3 (interferon regulatory factor 3) is required for the induction of proinflammatory cytokines and for endothelial cell proliferation. However, the effect and underlying mechanism of IRF3 on atherogenesis remain unknown. Our results demonstrated a moderate-to-strong immunoreactivity effect associated with IRF3 in the endothelium and macrophages of the atherosclerotic plaques in patients with coronary heart disease and in hyperlipidemic mice. IRF3
Indexed as
AnimalsApolipoproteins EAtherosclerosisCell Adhesion MoleculesCells, CulturedChemokinesDisease Models, AnimalHumansInterferon Regulatory Factor-3MacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutApolipoproteins ECell Adhesion MoleculesChemokinesInterferon Regulatory Factor-3atherosclerosisatherosclerotic plaquecoronary artery diseaseendothelial cellsinflammation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.