Evidence map›Paper›PMID 28115490›Full record

ArticleCirculation. Cardiovascular genetics2017

The Long Noncoding RNA Landscape of the Ischemic Human Left Ventricle.

Louis A Saddic, Martin I Sigurdsson, Tzuu-Wang Chang, Erica Mazaika, Mahyar Heydarpour, Stanton K Shernan, Christine E Seidman, Jon G Seidman, Sary F Aranki, Simon C Body and 1 more

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00985049 (Whole Genome Expression of Left Ventricular Myocardium During Cardiac Surgery), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00985049 recruitingnot on this map

Whole Genome Expression of Left Ventricular Myocardium During Cardiac Surgery

TypeobservationalSponsorBrigham and Women's HospitalRan2009 to 2025Enrolled350ConditionsCardiovascular Diseases
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Louis A SaddicFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (L.A.S., M.I.S., T.-W.C., M.H., S.K.S., S.C.B., J.D.M.), Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital (S.F.A.), and Department of Genetics (E.M., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.
Martin I SigurdssonFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (L.A.S., M.I.S., T.-W.C., M.H., S.K.S., S.C.B., J.D.M.), Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital (S.F.A.), and Department of Genetics (E.M., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.
Tzuu-Wang ChangFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (L.A.S., M.I.S., T.-W.C., M.H., S.K.S., S.C.B., J.D.M.), Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital (S.F.A.), and Department of Genetics (E.M., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.
Erica MazaikaFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (L.A.S., M.I.S., T.-W.C., M.H., S.K.S., S.C.B., J.D.M.), Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital (S.F.A.), and Department of Genetics (E.M., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.
Mahyar HeydarpourFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (L.A.S., M.I.S., T.-W.C., M.H., S.K.S., S.C.B., J.D.M.), Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital (S.F.A.), and Department of Genetics (E.M., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.
Stanton K ShernanFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (L.A.S., M.I.S., T.-W.C., M.H., S.K.S., S.C.B., J.D.M.), Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital (S.F.A.), and Department of Genetics (E.M., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.
Christine E SeidmanFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (L.A.S., M.I.S., T.-W.C., M.H., S.K.S., S.C.B., J.D.M.), Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital (S.F.A.), and Department of Genetics (E.M., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.
Jon G SeidmanFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (L.A.S., M.I.S., T.-W.C., M.H., S.K.S., S.C.B., J.D.M.), Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital (S.F.A.), and Department of Genetics (E.M., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.
Sary F ArankiFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (L.A.S., M.I.S., T.-W.C., M.H., S.K.S., S.C.B., J.D.M.), Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital (S.F.A.), and Department of Genetics (E.M., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.
Simon C BodyFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (L.A.S., M.I.S., T.-W.C., M.H., S.K.S., S.C.B., J.D.M.), Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital (S.F.A.), and Department of Genetics (E.M., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.
Jochen D MuehlschlegelFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (L.A.S., M.I.S., T.-W.C., M.H., S.K.S., S.C.B., J.D.M.), Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital (S.F.A.), and Department of Genetics (E.M., C.E.S., J.G.S.), Harvard Medical School, Boston, MA. jmuehlschlegel@partners.org.
Brigham and Women's Hospital · US

Funding

Defining Pathways from Gene Mutation to Heart FailureR01HL080494 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CHEN, CHRISTOPHER S, SEIDMAN, CHRISTINE E · 2005 to 2024
$9.4M
Molecular Signaling in Hypertrophic CardiomyopathyR01HL084553 · NHLBI · HARVARD MEDICAL SCHOOL · PI SEIDMAN, JONATHAN G · 2007 to 2022
$5.9M
Regulation of Cardiac Development in Health and DiseaseUM1HL098166 · NHLBI · HARVARD MEDICAL SCHOOL · PI PENNACCHIO, LEN ALEXANDER, PU, WILLIAM TSWENCHING · 2015 to 2019
$4.4M
Genetics of gene expression in human left ventricular myocardiumR01HL118266 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MUEHLSCHLEGEL, JOCHEN DANIEL · 2013 to 2017
$2.3M
NHLBI NIH HHS R01 HL080494NHLBI NIH HHS R01 HL084553NHLBI NIH HHS R01 HL118266NHLBI NIH HHS UM1 HL098166
6 · The paper itself

Abstract

backgroundThe discovery of functional classes of long noncoding RNAs (lncRNAs) has expanded our understanding of the variety of RNA species that exist in cells. In the heart, lncRNAs have been implicated in the regulation of development, ischemic and dilated cardiomyopathy, and myocardial infarction. Nevertheless, there is a limited description of expression profiles for these transcripts in human subjects. METHODS AND

resultsWe obtained left ventricular tissue from human patients undergoing cardiac surgery and used RNA sequencing to describe an lncRNA profile. We then identified a list of lncRNAs that were differentially expressed between pairs of samples before and after the ischemic insult of cardiopulmonary bypass. The expression of some of these lncRNAs correlates with ischemic time. Coding genes in close proximity to differentially expressed lncRNAs and coding genes that have coordinated expression with these lncRNAs are enriched in functional categories related to myocardial infarction, including heart function, metabolism, the stress response, and the immune system.

conclusionsWe describe a list of lncRNAs that are differentially expressed after ischemia in the human heart. These genes are predicted to function in pathways consistent with myocardial injury. As a result, lncRNAs may serve as novel diagnostic and therapeutic targets for ischemic heart disease. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00985049.

Indexed as

TranscriptomeAgedAged, 80 and overBiopsyCardiopulmonary BypassFemaleGene Expression ProfilingGene Expression RegulationHeart VentriclesHumansMaleMiddle AgedMyocardial IschemiaProspective StudiesRNA, Long NoncodingRNA, Long Noncodingaortic valvemyocardial infarctionmyocardial ischemianucleotidestranscriptional activation

Identifiers

PMID28115490
PMCPMC5302288
OpenAlexW2581021014

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.