ArticleJournal of neurology, neurosurgery, and psychiatry2017
Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies.
Article in Journal of neurology, neurosurgery, and psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach From the Writing Committee of the American Society for Apheresis: The Tenth Special Issue.Journal of clinical apheresis · 2026Guideline
- Retrograde Amnesia in LGI1 and CASPR2 Limbic Encephalitis: Two Case Reports and a Systematic Literature Review.European journal of neurology · 2025Pooled it
- Randomized Placebo-Controlled Trial of Intravenous Immunoglobulin in Autoimmune LGI1/CASPR2 Epilepsy.Annals of neurology · 2020Trial
- Seronegative Morvan Syndrome Presenting With Agrypnia Excitata and Peripheral Nerve Hyperexcitability: A Phenotype-Supported Diagnostic and Therapeutic Approach in a Resource-Limited Setting.Clinical case reports · 2026Article
- WONOEP XVII appraisal: The immunopathogenesis of epilepsy.Epilepsia · 2026Review
- High Relapse Rate in Anti-CASPR2 Disease: Implications for Prolonged Immunotherapy.Neurology(R) neuroimmunology & neuroinflammation · 2026Observational
- Neural synaptic vesicle autoimmunity following aerosolized porcine neural tissue exposure: insights into autoimmune inflammatory polyradiculoneuropathy.EBioMedicine · 2025Article
- Neuromyotonia and CASPR2 Antibodies: Electrophysiological Clues to Disease Pathophysiology.Biomolecules · 2025Review
- Successful treatment of morvan syndrome with efgartigimod: report of two cases.Journal of neurology · 2025Article
- Case Report: Anti-ADAM23 antibody: an overlooked autoantibody against VGKC-complex in autoimmune encephalitis.Frontiers in immunology · 2025Article
- Anti-septin complex positive autoimmune encephalitis after severe falciparum malaria: a case report.Malaria journal · 2024Article
- Cancer Therapy-Induced Encephalitis.Cancers · 2024Review
- Anti-contact protein-associated protein 2 antibody encephalitis in children: A case report.World journal of clinical cases · 2024Article
- Molecular dissection of an immunodominant epitope in KFrontiers in immunology · 2024Article
- Review
- Searching for Neuronal Antibodies in Psychiatric Diseases: Uncertain Findings and Implications.Neurology · 2023Article
- Neuroimaging characteristics may aid in diagnosis, subtyping, and prognosis in autoimmune encephalitis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Use of anti-seizure medications in different types of autoimmune encephalitis: A narrative review.Frontiers in neurology · 2023Review
- Parallel roles of neuroinflammation in feline and human epilepsies.Veterinary journal (London, England : 1997) · 2022Review
- The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis.Molecular psychiatry · 2022Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesAutoantibodies against the extracellular domains of the voltage-gated potassium channel (VGKC) complex proteins, leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-2 (CASPR2), are found in patients with limbic encephalitis, faciobrachial dystonic seizures, Morvan's syndrome and neuromyotonia. However, in routine testing, VGKC complex antibodies without LGI1 or CASPR2 reactivities (double-negative) are more common than LGI1 or CASPR2 specificities. Therefore, the target(s) and clinical associations of double-negative antibodies need to be determined.
methodsSera (n=1131) from several clinically defined cohorts were tested for IgG radioimmunoprecipitation of radioiodinated α-dendrotoxin (
resultsVGKC complex antibodies were found in 162 of 1131 (14%) sera. 90 of these (56%) had antibodies targeting the extracellular domains of LGI1 or CASPR2. Of the remaining 72 double-negative sera, 10 (14%) immunoprecipitated
conclusionsDouble-negative VGKC complex antibodies are often directed against cytosolic epitopes of Kv1 subunits and occasionally against non-mammalian αDTX. These antibodies should no longer be classified as neuronal-surface antibodies. They consequently lack pathogenic potential and do not in themselves support the use of immunotherapies.
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