Evidence map›Paper›PMID 28115347›Full record

ArticleAntimicrobial agents and chemotherapy2017

Perturbations of Phosphatidate Cytidylyltransferase (CdsA) Mediate Daptomycin Resistance in Streptococcus mitis/oralis by a Novel Mechanism.

Nagendra N Mishra, Truc T Tran, Ravin Seepersaud, Cristina Garcia-de-la-Maria, Kym Faull, Alex Yoon, Richard Proctor, Jose M Miro, Michael J Rybak, Arnold S Bayer and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
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  4. Identification ofJournal of bacteriology · 2024
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  5. Pan-genome analysis ofFrontiers in microbiology · 2024
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  6. Review
  7. Article
  8. Membrane Phenotypic, Metabolic and Genotypic Adaptations ofAntibiotics (Basel, Switzerland) · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. New Mutations inFrontiers in microbiology · 2022
    Article
  15. Review
  16. Development of High-Level Daptomycin Resistance inAntimicrobial agents and chemotherapy · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Recent applications of mass spectrometry in bacterial lipidomics.Analytical and bioanalytical chemistry · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

Nagendra N MishraLA Biomedical Research Institute, Torrance, California, USA.
Truc T TranCenter for Antimicrobial Resistance and Microbial Genomics, Division of Infectious Diseases, University of Texas McGovern School of Medicine, Houston, Texas, USA.
Ravin SeepersaudUniversity of California, San Francisco, California, USA.
Cristina Garcia-de-la-MariaHospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
Kym FaullGeffen School of Medicine at UCLA, Los Angeles, California, USA.
Alex YoonGeffen School of Medicine at UCLA, Los Angeles, California, USA.
Richard ProctorDepartments of Medical Microbiology & Immunology and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Jose M MiroHospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
Michael J RybakAnti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
Arnold S BayerLA Biomedical Research Institute, Torrance, California, USA abayer@labiomed.org cesar.arias@uth.tmc.edu.
Cesar A AriasCenter for Antimicrobial Resistance and Microbial Genomics, Division of Infectious Diseases, University of Texas McGovern School of Medicine, Houston, Texas, USA abayer@labiomed.org cesar.arias@uth.tmc.edu.
Paul M SullamUniversity of California, San Francisco, California, USA.
University of California, Los Angeles · USSan Francisco VA Medical Center · USUniversitat de Barcelona · ESThe Lundquist Institute · USThe University of Texas Health Science Center at Houston · USUniversidad El Bosque · COUniversity of Wisconsin–Madison · USWayne State University · US

Funding

STREPTOCOCCAL PLATELET BINDING AND ENDOCARDITISR01AI041513 · NIAID · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI SULLAM, PAUL M. · 1997 to 2019
$5.6M
Staphylococcal Adaptations to Platelet Microbicidal ProteinR01AI039108 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI BAYER, ARNOLD S · 1997 to 2016
$5.1M
Mechanisms for ligand binding by serine-rich adhesins of Gram-positive pathogensR01AI106987 · NIAID · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI IVERSON, T M, SULLAM, PAUL M. · 2014 to 2018
$3.4M
Molecular Mechanisms Of Daptomycin Resistance In EnterococciR01AI093749 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2011 to 2015
$1.9M
POR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5M
Daptomycin Resistance in Enterococcus faeciumK08AI113317 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TRAN, TRUC THANH · 2014 to 2018
$792k
MINING THE ORAL MICROBIOME FOR NOVEL GLYCAN-BINDING MOLECULESR21DE025826 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI RUHL, STEFAN HANS-KLAUS, SULLAM, PAUL M. · 2015 to 2016
$638k
Molecular basis of the cefazolin inoculum effectR21AI143229 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2019 to 2020
$442k
Characterization of LiaR from multidrug-resistant E. faeciumR21AI114961 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2015 to 2016
$438k
Impact of daptomycin dose exposure on biofilm embedded Enterococci resistanceR21AI109266 · NIAID · WAYNE STATE UNIVERSITY · PI RYBAK, MICHAEL JOSEPH · 2014 to 2015
$380k
Targeting Cell Membrane Adaptation in Multidrug-Resistant Enterococcus faeciumR21AI121519 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2017
$226k
The accessory Sec system of Gram-positive pathogensI01BX001653 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI SULLAM, PAUL M. · 2013 to 2016
–
BLRD VA I01 BX001653NIAID NIH HHS K08 AI113317NIAID NIH HHS K24 AI121296NIAID NIH HHS R01 AI039108NIAID NIH HHS R01 AI041513NIAID NIH HHS R01 AI093749NIAID NIH HHS R01 AI106987NIAID NIH HHS R21 AI109266NIAID NIH HHS R21 AI114961NIAID NIH HHS R21 AI121519NIAID NIH HHS R21 AI143229NIDCR NIH HHS R21 DE025826
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsCytidine DiphosphateDaptomycinDrug Resistance, BacterialGram-Positive BacteriaMicrobial Sensitivity TestsNeutrophilsNucleotidyltransferasesStreptococcus oralisAnti-Bacterial AgentsCytidine DiphosphateDaptomycinNucleotidyltransferasesphosphatidate cytidylyltransferasedaptomycin resistancephosphatidate cytidylyltransferaseStreptococcus mitis/oralis

Identifiers

PMID28115347
PMCPMC5365703
OpenAlexW2580053381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.