Evidence map›Paper›PMID 28115217›Full record

ArticleThe Journal of allergy and clinical immunology2017

Cysteinyl leukotriene E

Maryam Salimi, Linda Stöger, Wei Liu, Simei Go, Ian Pavord, Paul Klenerman, Graham Ogg, Luzheng Xue

Open access · hybridAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 152 citations in OpenAlex.

  1. Article
  2. Group 2 innate lymphoid cells: Where are we 15 years out?The Journal of allergy and clinical immunology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. The immunoproteasome regulates ILC2 responses by modulating mitochondrial capacity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Platelets engage mast cells in a bilateral IL-33-driven feed-forward loop.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Mast Cells in Aspirin-Exacerbated Respiratory Disease.Current allergy and asthma reports · 2024
    Review
  20. Group 2 Innate Lymphoid Cells in Allergic Rhinitis.Journal of inflammation research · 2024
    Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maryam SalimiMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, NIHR Biomedical Research Centre, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Linda StögerRespiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford NIHR Biomedical Research Centre, Core Translational Immunology Laboratory, Oxford, United Kingdom.
Wei LiuRespiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Simei GoRespiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Ian PavordRespiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Paul KlenermanTranslational Gastroenterology Unit, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Graham OggMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, NIHR Biomedical Research Centre, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Luzheng XueRespiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford NIHR Biomedical Research Centre, Core Translational Immunology Laboratory, Oxford, United Kingdom. Electronic address: luzheng.xue@ndm.ox.ac.uk.
University of Oxford · GBJohn Radcliffe Hospital · GB

Funding

Medical Research Council MC_U137881017Medical Research Council MC_UU_12010/5Wellcome Trust 109965/Z/15/Z
6 · The paper itself

Abstract

backgroundGroup 2 innate lymphoid cells (ILC2s) are a potential innate source of type 2 cytokines in the pathogenesis of allergic conditions. Epithelial cytokines (IL-33, IL-25, and thymic stromal lymphopoietin [TSLP]) and mast cell mediators (prostaglandin D

objectivesWe sought to determine the role of cysLTs and their relationship with other ILC2 stimulators in the activation of human ILC2s.

methodsFor ex vivo studies, fresh blood from patients with atopic dermatitis and healthy control subjects was analyzed with flow cytometry. For in vitro studies, ILC2s were isolated and cultured. The effects of cysLTs, PGD

resultsHuman ILC2s expressed the LT receptor CysLT

conclusionCysLTs, particularly LTE

Indexed as

AdultCells, CulturedCytokinesDermatitis, AtopicEicosanoic AcidsEpithelial CellsFemaleHumansImmunity, InnateLeukotriene E4LymphocytesMaleMast CellsProstaglandin D2Th2 Cellsarachidic acidCytokinesEicosanoic AcidsLeukotriene E4Prostaglandin D2atopic dermatitisGroup 2 innate lymphoid cellIL-2IL-25IL-33leukotriene E(4)prostaglandin D(2)thymic stromal lymphopoietin

Identifiers

PMID28115217
PMCPMC5624780
OpenAlexW2576968561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.