Evidence map›Paper›PMID 28115016›Full record

SynthesisJournal of orthopaedic surgery and research2017

The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials.

Longxiang Shen, Ting Yuan, Shengbao Chen, Xuetao Xie, Changqing Zhang

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of orthopaedic surgery and research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07339137 (The Effects of Platelet-rich Plasma), which is not on this map. Cited by 147 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 16 pooled it
40.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07339137 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Effects of Platelet-rich Plasma (PRP) Injections Administered Into Intra-articular and Periarticular Regions Under Ultrasound Guidance in Chronic Knee Osteoarthritis on Pain, Function, Activities of Daily Living, Medial Collateral Ligament (MCL) and Distal Femoral Cartilage Thickness

TypeinterventionalSponsorAnkara City Hospital BilkentRan2025 to 2026Enrolled42ConditionsPlatelet Rich Plasma Injection, Ultrasonography, GonarthrosisArmsConservative Therapy, Intra-Articular PRP, Peri-Articular PRP
3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 16 syntheses or guidelines pooled it, 367 citations in OpenAlex.

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  6. Cell therapies for chondral defects of the talus: a systematic review.Journal of orthopaedic surgery and research · 2022
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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Longxiang ShenDepartment of Orthopaedic Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, 600 Yishan Road, Shanghai, 200233, China.
Ting YuanDepartment of Orthopaedic Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, 600 Yishan Road, Shanghai, 200233, China.
Shengbao ChenSection of Clinical Epidemiology, Institute of Orthopaedic Traumatology affiliated to Shanghai Jiaotong University, 600 Yishan Road, Shanghai, 200233, China.
Xuetao XieDepartment of Orthopaedic Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, 600 Yishan Road, Shanghai, 200233, China. xuetaoxie@163.com.
Changqing ZhangDepartment of Orthopaedic Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, 600 Yishan Road, Shanghai, 200233, China.
Shanghai Sixth People's Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQuite a few randomized controlled trials (RCTs) investigating the efficacy of platelet-rich plasma (PRP) for treatment of knee osteoarthritis (OA) have been recently published. Therefore, an updated systematic review was performed to evaluate the temporal effect of PRP on knee pain and physical function.

methodsPubmed, Embase, Cochrane library, and Scopus were searched for human RCTs comparing the efficacy and/or safety of PRP infiltration with other intra-articular injections. A descriptive summary and quality assessment were performed for all the studies finally included for analysis. For studies reporting outcomes concerning Western Ontario and McMaster Universities Arthritis Index (WOMAC) or adverse events, a random-effects model was used for data synthesis.

resultsFourteen RCTs comprising 1423 participants were included. The control included saline placebo, HA, ozone, and corticosteroids. The follow-up ranged from 12 weeks to 12 months. Risk of bias assessment showed that 4 studies were considered as moderate risk of bias and 10 as high risk of bias. Compared with control, PRP injections significantly reduced WOMAC pain subscores at 3, 6, and 12 months follow-up (p = 0.02, 0.004, <0.001, respectively); PRP significantly improved WOMAC physical function subscores at 3, 6, and 12 months (p = 0.002, 0.01, <0.001, respectively); PRP also significantly improved total WOMAC scores at 3, 6 and 12 months (all p < 0.001); nonetheless, PRP did not significantly increased the risk of post-injection adverse events (RR, 1.40 [95% CI, 0.80 to 2.45], I

conclusionsIntra-articular PRP injections probably are more efficacious in the treatment of knee OA in terms of pain relief and self-reported function improvement at 3, 6 and 12 months follow-up, compared with other injections, including saline placebo, HA, ozone, and corticosteroids. REVIEW REGISTRATION: PROSPERO CRD42016045410 . Registered 8 August 2016.

Indexed as

Platelet-Rich PlasmaHumansHyaluronic AcidOsteoarthritis, KneePainPain MeasurementRadiographyRandomized Controlled Trials as TopicRecovery of FunctionSeverity of Illness IndexTreatment OutcomeHyaluronic AcidHyaluronic acidKneeOsteoarthritisPlatelet-rich plasmaSystematic review

Identifiers

PMID28115016
PMCPMC5260061
OpenAlexW2582012588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.