ArticleJournal of neuroinflammation2017
Th17-skewed immune response and cluster of differentiation 40 ligand expression in canine steroid-responsive meningitis-arteritis, a large animal model for neutrophilic meningitis.
Article in Journal of neuroinflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- The canine blood-brain barrier in health and disease: focus on brain protection.The veterinary quarterly · 2025Review
- A New Method of Canine CD4International journal of molecular sciences · 2025Article
- Article
- Neutrophil extracellular traps in CSF and serum of dogs with steroid-responsive meningitis-arteritis.PloS one · 2024Article
- Elevated Interleukin-31 Levels in Serum, but Not CSF of Dogs with Steroid-Responsive Meningitis-Arteritis Suggest an Involvement in Its Pathogenesis.Animals : an open access journal from MDPI · 2023Article
- Long-term changes of Th17 and regulatory T cells in peripheral blood of dogs with spinal cord injury after intervertebral disc herniation.BMC veterinary research · 2023Article
- Signalment and C-reactive protein values in dogs with immune-mediated polyarthritis and steroid responsive meningitis arteritis.Frontiers in veterinary science · 2023Article
- Article
- Magnetic resonance imaging highlights the meningeal involvement in steroid responsive meningitis-arteritis and suggests the inflammation of the surrounding tissues (70 cases).Frontiers in veterinary science · 2022Article
- Th17 cell-mediated immune response in a subpopulation of dogs with idiopathic epilepsy.PloS one · 2022Article
- Detection of Extracellular Traps in Canine Steroid-Responsive Meningitis-Arteritis.Frontiers in veterinary science · 2022Article
- Differential T-cell responses in dogs with meningoencephalomyelitis of unknown origin compared to healthy controls.Frontiers in veterinary science · 2022Article
- Serum interleukin 17 concentrations in dogs with immune-mediated hemolytic anemia.Journal of veterinary internal medicine · 2021Article
- Evaluation of the involvement of Th17-cells in the pathogenesis of canine spinal cord injury.PloS one · 2021Article
- Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid-responsive meningitis-arteritis.Journal of veterinary internal medicine · 2019Article
- Evaluation of IL-1β levels in epilepsy and traumatic brain injury in dogs.BMC neuroscience · 2019Article
- Measurement of Neutrophil Gelatinase-Associated Lipocalin Concentration in Canine Cerebrospinal Fluid and Serum and Its Involvement in Neuroinflammation.Frontiers in veterinary science · 2019Article
- Syphilis Infection Differentially Regulates the Phenotype and Function of γδ T Cells in HIV-1-Infected Patients Depends on the HIV-1 Disease Stage.Frontiers in immunology · 2017Article
- Investigation of the presence of specific neural antibodies in dogs with epilepsy or dyskinesia using murine and human assays.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSteroid-responsive meningitis-arteritis (SRMA) is an immune-mediated disorder characterized by neutrophilic pleocytosis and an arteritis particularly in the cervical leptomeninges. Previous studies of the disease have shown increased levels of IL-6 and TGF-ß
methodsAn enzyme-linked immunosorbent assay (ELISA) was performed to measure IL-17 and CD40L in serum and CSF from a total of 79 dogs. Measurements of patients suffering from SRMA in the acute state (SRMA A) were compared with levels of patients under treatment with steroids (SRMA T), recurrence of the disease (SRMA R), other neurological disorders, and healthy dogs, using the two-part test. Additionally, secretion of IL-17 and interferon gamma (IFN-γ) from the peripheral blood mononuclear cells (PBMCs) was confirmed by an enzyme-linked immunospot (ELISpot) assay.
resultsSignificant higher levels of IL-17 were found in CSF of dogs with SRMA A compared with SRMA T, other neurological disorders and healthy dogs (p < 0.0001). In addition, levels of CD40L in CSF in dogs with SRMA A and SRMA R were significantly higher than in those with SRMA T (p = 0.0004) and healthy controls (p = 0.014). Furthermore, CSF concentrations of IL-17 and CD40L showed a strong positive correlation among each other (rSpear = 0.6601; p < 0.0001) and with the degree of pleocytosis (rSpear = 0.8842; p < 0.0001 and rSpear = 0.6649; p < 0.0001, respectively). IL-17 synthesis from PBMCs in SRMA patients was confirmed; however, IL-17 is mainly intrathecally produced.
conclusionsThese results imply that Th17 cells are inducing the autoimmune response in SRMA and are involved in the severe neutrophilic pleocytosis and disruption of the blood-brain barrier (BBB). CD-40L intrathecal synthesis might be involved in the striking vasculitis. The investigation of the role of IL-17 in SRMA might elucidate important pathomechanism and open new therapeutic strategies.
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