ArticleBMC complementary and alternative medicine2017
Panaxatriol saponins promotes angiogenesis and enhances cerebral perfusion after ischemic stroke in rats.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Natural herbal extract roles and mechanisms in treating cerebral ischemia: A systematic review.Frontiers in pharmacology · 2024Pooled it
- Panax notoginseng preparation plus aspirinFrontiers in pharmacology · 2022Pooled it
- Comparative efficacy of Chinese herbal injections for treating acute cerebral infarction: a network meta-analysis of randomized controlled trials.BMC complementary and alternative medicine · 2018Pooled it
- Efficacy and Safety of Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Structural and morphological modulation of the myocardium byBiochemistry and biophysics reports · 2026Article
- Efficacy of Panax notoginseng saponins on functional outcome in obese patients with acute ischemic stroke.Journal of ginseng research · 2026Article
- Protective effects of ginsenosides in cerebral small vessel disease: Cellular and molecular mechanisms.Journal of ginseng research · 2025Review
- Targeted inhibition of macrophage STING signaling alleviates inflammatory injury and ventricular remodeling in acute myocardial infarction.Acta pharmaceutica Sinica. B · 2025Article
- MicroRNA-21a-5p Promotes Cerebral Angiogenesis in Transient Ischemic Attack by Targeting RBMS3 and Subsequently Modulating the TGFBR1/SMAD2/3 Pathway.CNS neuroscience & therapeutics · 2025Article
- Effect of age on the efficacy and safety of Panax notoginseng saponins in acute ischemic stroke: a prespecified secondary analysis of the PANDA study.Chinese medicine · 2025Article
- Therapeutic potential of natural products in ischemic stroke: targeting angiogenesis.Frontiers in pharmacology · 2025Review
- Pickering emulsion loaded with total flavonoids fromFrontiers in bioengineering and biotechnology · 2025Article
- Analysis of online prescription patterns in Chinese patients with sequelae of cerebral infarction: a real-world study.Scientific reports · 2024Article
- Naodesheng decoction regulating vascular function via G-protein-coupled receptors: network analysis and experimental investigations.Frontiers in pharmacology · 2024Article
- Structural Characters and Pharmacological Activity of Protopanaxadiol-Type Saponins and Protopanaxatriol-Type Saponins from Ginseng.Advances in pharmacological and pharmaceutical sciences · 2024Review
- Gut microbiota, a hidden protagonist of traditional Chinese medicine for acute ischemic stroke.Frontiers in pharmacology · 2023Review
- Neuroprotective effects of Korean White ginseng and Red ginseng in an ischemic stroke mouse model.Journal of ginseng research · 2022Article
- Neuroprotective Effect of Taohong Siwu Decoction on Cerebral Ischemia/Reperfusion InjuryFrontiers in pharmacology · 2022Article
- Pretreatment with Panaxatriol Saponin Attenuates Mitochondrial Apoptosis and Oxidative Stress to Facilitate Treatment of Myocardial Ischemia-Reperfusion Injury via the Regulation of Keap1/Nrf2 Activity.Oxidative medicine and cellular longevity · 2022Article
- Sodium tanshinone IIA sulfonate ameliorates cerebral ischemic injury through regulation of angiogenesis.Experimental and therapeutic medicine · 2021Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPanaxatriol saponins (PTS), an extract from the traditional Chinese herb Panax notoginseng, which has been used to treat ischemic stroke for many years in China. However, the mechanism underlying the effects of PTS remains unclear. This study aimed to determine whether PTS can protect against ischemic brain injury by promoting angiogenesis and to explore the possible mechanism by which it promotes angiogenesis.
methodsMiddle cerebral artery occlusion (MCAO) was induced in rats, and neurological deficit scores and brain infarct volumes were assessed. Micro-Positron emission tomography (PET) was adopted to assess cerebral perfusion, and real-time PCR and western blotting were used to evaluate vascular growth factor and Sonic hedgehog (Shh) pathway component levels. Immunofluorescence staining was used to determine capillary densities in ischemic penumbrae.
resultsWe showed that PTS improved neurological function and reduced infarct volumes in MCAO rats. Micro-PET indicated that PTS can significantly increase
conclusionThese findings indicate that PTS exerts protective effects against cerebral ischemic injury by enhancing angiogenesis and improving microperfusion.
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