Evidence map›Paper›PMID 28114977›Full record

ArticleStem cell research & therapy2017

Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice.

Zhen Wang, Yueling Wang, Ting Yang, Jing Li, Xinyuan Yang

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 121 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 3 pooled it
20.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 3 syntheses or guidelines pooled it, 240 citations in OpenAlex.

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  19. hnRNPA2B1 restrains granulosa cell ferroptosis by mJournal of ovarian research · 2025
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhen WangDepartment of Gynecology and Obstetrics, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Yueling WangDepartment of Gynecology and Obstetrics, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Ting YangDepartment of Gynecology and Obstetrics, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Jing LiCenter for Translational Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Xinyuan YangDepartment of Gynecology and Obstetrics, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China. m18991232845@163.com.
First Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundYoung female patients who receive chemotherapy frequently face premature ovarian failure (POF). The therapeutic potential of stem cells in these patients has been explored in stem cells derived from different sources. However, many of these types of stem cells are either difficult to obtain or obtaining them involves invasive procedures. Here, we show that menstrual-derived stem cells (MenSCs) are easy to access and exhibit mesenchymal stem cell-like properties. MenSCs are therefore a novel source of stem cells that can be used for tissue repair. The aim of this study was to explore the reparative capacity and the mechanism underlying the activities of MenSCs.

methodsPOF mouse models were established by 7 consecutive days of intraperitoneal injection of cisplatin, and then MenSCs or MenSC-derived conditioned media (CM) were infused via the tail vein. The ovaries were excised after either 7 or 21 days of treatment and the follicles were counted and categorized. Apoptosis of granulosa cells was observed by terminal deoxynucleotidyl transferase mediated dUTP nick end labelling staining. Ovarian function was evaluated by monitoring serum sex hormone levels. Furthermore, MenSC tracking, Q-PCR, and small interfering RNA transfection were used to reveal the inner mechanism of repair.

resultsMenSC transplantation could improve the ovarian microenvironment by reducing apoptosis in granulosa cells and the fibrosis of ovarian interstitium, which contributes to increase the follicular numbers and return sex hormone levels to normal values. Meanwhile, the transplanted MenSCs directively migrate to ovarian interstitium to play a role in repair rather than differentiate to oocytes directly. Additionally, MenSCs and CM derived from these cells exerted protective effects on damaged ovaries partially by secreting FGF2.

conclusionMenSCs repair ovarian injury, improve ovarian function, and stimulate regeneration, suggesting that transplantation of MenSCs may provide an effective and novel method for treating POF.

Indexed as

Stem Cell TransplantationAnimalsApoptosisCell DifferentiationCells, CulturedCisplatinCulture Media, ConditionedCytogenetic AnalysisCytokinesDisease Models, AnimalFemaleFibroblast Growth Factor 2Granulosa CellsKaryotypeMenstruationMiceCisplatinCulture Media, ConditionedCytokinesFibroblast Growth Factor 2RNA, Small InterferingFibroblast growth factor 2Menstrual-derived stem cellsParacrinePremature ovarian failure

Identifiers

PMID28114977
PMCPMC5259841
OpenAlexW2580328223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.