ArticleStem cell research & therapy2017
Optimizing mesoderm progenitor selection and three-dimensional microniche culture allows highly efficient endothelial differentiation and ischemic tissue repair from human pluripotent stem cells.
Article in Stem cell research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- 3D bioprinted human vascular organoid sheets promote functional ischemic repair and exhibit adaptive in vivo remodeling.BMC medicine · 2026Article
- Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026Review
- Skeletal stem cells, a new direction for the treatment of bone and joint diseases.World journal of orthopedics · 2025Review
- Microgel-based carriers enhance skeletal stem cell reprogramming towards immunomodulatory phenotype in osteoarthritic therapy.Bioactive materials · 2024Article
- Human Pluripotent Stem Cells Derived Endothelial Cells Repair Choroidal Ischemia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Injectable cartilage microtissues based on 3D culture using porous gelatin microcarriers for cartilage defect treatment.Regenerative biomaterials · 2024Article
- Single-cell atlas of multilineage cardiac organoids derived from human induced pluripotent stem cells.Life medicine · 2022Article
- Functional Characterization of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells.International journal of molecular sciences · 2022Article
- Progress in multicellular human cardiac organoids for clinical applications.Cell stem cell · 2022Review
- A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types.Cell communication and signaling : CCS · 2022Article
- Transferrin improved the generation of cardiomyocyte from human pluripotent stem cells for myocardial infarction repair.Journal of molecular histology · 2021Article
- Integrative Analysis of DNA Methylation and Gene Expression Profiles Identifies Colorectal Cancer-Related Diagnostic Biomarkers.Pathology oncology research : POR · 2021Article
- Homozygous MESP1 knock-in reporter hESCs facilitated cardiovascular cell differentiation and myocardial infarction repair.Theranostics · 2020Article
- Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program.Protein & cell · 2019Article
- Biphasic modulation of insulin signaling enables highly efficient hematopoietic differentiation from human pluripotent stem cells.Stem cell research & therapy · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGeneration of large quantities of endothelial cells is highly desirable for vascular research, for the treatment of ischemia diseases, and for tissue regeneration. To achieve this goal, we developed a simple, chemically defined culture system to efficiently and rapidly differentiate endothelial cells from human pluripotent stem cells by going through an MESP1 mesoderm progenitor stage.
methodsMesp1 is a key transcription factor that regulates the development of early cardiovascular tissue. Using an MESP1-mTomato knock-in reporter human embryonic stem cell line, we compared the gene expression profiles of MESP1
resultsMESP1
conclusionsOur study demonstrates that combining MESP1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.