Evidence map›Paper›PMID 28114831›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2017

Screening assay for inhibitors of a recombinant Streptococcus pneumoniae UDP-glucose pyrophosphorylase.

Agustín Zavala, Verónica Kovacec, Gustavo Levín, Albertina Moglioni, María Victoria Miranda, Ernesto García, Laura Bonofiglio, Marta Mollerach

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Immobilization of the Highly Active UDP-Glucose Pyrophosphorylase FromFrontiers in bioengineering and biotechnology · 2020
    Article
  2. Frontiers in microbiology · 2020
    Article
  3. TargetingDrug target insights · 2020
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Agustín Zavalaa Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología , Inmunología y Biotecnología, Cátedra de Microbiología , Buenos Aires , Argentina.
Verónica Kovaceca Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología , Inmunología y Biotecnología, Cátedra de Microbiología , Buenos Aires , Argentina.
Gustavo Levínb Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología , Inmunología y Biotecnología, Cátedra de Biotecnología , Buenos Aires , Argentina.
Albertina Moglionic Departamento de Farmacología, Facultad de Farmacia y Bioquímica , Cátedra de Química Medicinal, Universidad de Buenos Aires , Buenos Aires , Argentina.
María Victoria Mirandab Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología , Inmunología y Biotecnología, Cátedra de Biotecnología , Buenos Aires , Argentina.
Ernesto Garcíad Centro de Investigaciones Biológicas, CSIC and CIBER de Enfermedades Respiratorias (CIBERES) , Madrid , Spain.
Laura Bonofiglioa Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología , Inmunología y Biotecnología, Cátedra de Microbiología , Buenos Aires , Argentina.
Marta Molleracha Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología , Inmunología y Biotecnología, Cátedra de Microbiología , Buenos Aires , Argentina.
University of Buenos Aires · ARCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The UDP-glucose pyrophosphorylase of Streptococcus pneumoniae (GalU

Indexed as

Anti-Bacterial AgentsDose-Response Relationship, DrugDrug Evaluation, PreclinicalEnzyme InhibitorsMicrobial Sensitivity TestsMolecular StructureRecombinant ProteinsStreptococcus pneumoniaeStructure-Activity RelationshipUTP-Glucose-1-Phosphate UridylyltransferaseAnti-Bacterial AgentsEnzyme InhibitorsRecombinant ProteinsUTP-Glucose-1-Phosphate UridylyltransferaseAntibacterial targetpneumococcusUTP:glucose 1-phosphate uridylyltransferasevirulence inhibitors

Identifiers

PMID28114831
PMCPMC6009895
OpenAlexW2581473660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.