Evidence map›Paper›PMID 28114821›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2017

Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives.

Jean Guillon, Anita Cohen, Nassima Meriem Gueddouda, Rabindra Nath Das, Stéphane Moreau, Luisa Ronga, Solène Savrimoutou, Louise Basmaciyan, Alix Monnier, Myriam Monget and 6 more

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. InClACS omega · 2024
    Article
  4. Article
  5. Article
  6. G-Quadruplexes as Key Transcriptional Regulators in Neglected Trypanosomatid Parasites.Chembiochem : a European journal of chemical biology · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jean Guillona ARNA Laboratory , University Bordeaux, UFR des Sciences Pharmaceutiques , Bordeaux , France.
Anita Cohenc UMR-MD3, Faculty of Pharmacy , Aix-Marseille University, Laboratory of Parasitology , Marseille , France.
Nassima Meriem Gueddoudaa ARNA Laboratory , University Bordeaux, UFR des Sciences Pharmaceutiques , Bordeaux , France.
Rabindra Nath Dasa ARNA Laboratory , University Bordeaux, UFR des Sciences Pharmaceutiques , Bordeaux , France.
Stéphane Moreaua ARNA Laboratory , University Bordeaux, UFR des Sciences Pharmaceutiques , Bordeaux , France.
Luisa Rongaa ARNA Laboratory , University Bordeaux, UFR des Sciences Pharmaceutiques , Bordeaux , France.
Solène Savrimoutoua ARNA Laboratory , University Bordeaux, UFR des Sciences Pharmaceutiques , Bordeaux , France.
Louise Basmaciyanc UMR-MD3, Faculty of Pharmacy , Aix-Marseille University, Laboratory of Parasitology , Marseille , France.
Alix Monniera ARNA Laboratory , University Bordeaux, UFR des Sciences Pharmaceutiques , Bordeaux , France.
Myriam Mongeta ARNA Laboratory , University Bordeaux, UFR des Sciences Pharmaceutiques , Bordeaux , France.
Sandra Rubioa ARNA Laboratory , University Bordeaux, UFR des Sciences Pharmaceutiques , Bordeaux , France.
Timothée Garnerind Université de Picardie Jules Verne, Laboratoire de Glycochimie , des Antimicrobiens et des Agroressouces, UMR CNRS 7378, UFR de Pharmacie , Amiens , France.
Nadine Azasc UMR-MD3, Faculty of Pharmacy , Aix-Marseille University, Laboratory of Parasitology , Marseille , France.
Jean-Louis Mergnya ARNA Laboratory , University Bordeaux, UFR des Sciences Pharmaceutiques , Bordeaux , France.
Catherine Mulliéd Université de Picardie Jules Verne, Laboratoire de Glycochimie , des Antimicrobiens et des Agroressouces, UMR CNRS 7378, UFR de Pharmacie , Amiens , France.
Pascal Sonnetd Université de Picardie Jules Verne, Laboratoire de Glycochimie , des Antimicrobiens et des Agroressouces, UMR CNRS 7378, UFR de Pharmacie , Amiens , France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel series of bis- and tris-pyrrolo[1,2-a]quinoxaline derivatives 1 were synthesized and tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium falciparum strains. Biological results showed good antimalarial activity with IC

Indexed as

Drug DesignAntiprotozoal AgentsCell SurvivalDose-Response Relationship, DrugHep G2 CellsHumansLeishmania donovaniMolecular StructurePlasmodium falciparumPropylaminesQuinoxalinesStructure-Activity RelationshipAntiprotozoal Agentsbis(N-((pyrrolo(1,2-a)quinoxalin-4-yl)benzyl)-3-aminopropyl)aminePropylaminesQuinoxalinesantileishmanial activityAntimalarial activitybis-pyrrolo[1,2-a]quinoxalineG-quadruplexPlasmodium falciparum

Identifiers

PMID28114821
PMCPMC6445168

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.