ArticleNature neuroscience2017
An intra-amygdala circuit specifically regulates social fear learning.
Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed.
- The behavioral and neural architecture of observational active avoidance is shaped by demonstrator experience and observer sex.Scientific reports · 2026Article
- Empathy and prosocial behavior powered by orexin-driven theta oscillations.Science (New York, N.Y.) · 2026Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- The Amygdala Regulates Social Motivation for Selective Vocal Imitation in Zebra Finches.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neurexin1α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia.Psychopharmacology · 2025Article
- A localized tracing technique to explore intra-amygdala functional and structural correlates of individual variability in behavioral response.Frontiers in molecular neuroscience · 2025Article
- Shaping behaviors through social experience and their proposed sensitivity to stress.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Distinct medial amygdala oxytocin receptor neurons projections respectively control consolation or aggression in male mandarin voles.Nature communications · 2024Article
- Activation of NPY Receptors in the BLA Inhibits Projections to the Bed Nucleus of the Stria Terminalis and Buffers Stress-Induced Decreases in Social Interaction in Male Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A novel paradigm for observational learning in rats.Cognitive neurodynamics · 2024Article
- Synchronized LFP rhythmicity in the social brain reflects the context of social encounters.Communications biology · 2024Article
- Understanding Others' Distress Through Past Experiences: The Role of Memory Engram Cells in Observational Fear.Advances in neurobiology · 2024Review
- Indirectly acquired fear memories have distinct, sex-specific molecular signatures from directly acquired fear memories.PloS one · 2024Article
- Emotional Contagion and Social Support in Pigs with the Negative Stimulus.Animals : an open access journal from MDPI · 2023Article
- Systems consolidation induces multiple memory engrams for a flexible recall strategy in observational fear memory in male mice.Nature communications · 2023Article
- How social information impacts action in rodents and humans: the role of the prefrontal cortex and its connections.Neuroscience and biobehavioral reviews · 2023Review
- Patterns of Arc mRNA expression in the rat brain following dual recall of fear- and reward-based socially acquired information.Scientific reports · 2023Article
- Hemispherically lateralized rhythmic oscillations in the cingulate-amygdala circuit drive affective empathy in mice.Neuron · 2023Article
- Neural circuits regulating prosocial behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Neurexin1α knockout rats display oscillatory abnormalities and sensory processing deficits back-translating key endophenotypes of psychiatric disorders.Translational psychiatry · 2022Article
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5 authors.
Funding
Abstract
Adaptive social behavior requires transmission and reception of salient social information. Impairment of this reciprocity is a cardinal symptom of autism. The amygdala is a critical mediator of social behavior and is implicated in social symptoms of autism. Here we found that a specific amygdala circuit, from the lateral nucleus to the medial nucleus (LA-MeA), is required for using social cues to learn about environmental cues that signal imminent threats. Disruption of the LA-MeA circuit impaired valuation of these environmental cues and subsequent ability to use a cue to guide behavior. Rats with impaired social guidance of behavior due to knockout of Nrxn1, an analog of autism-associated gene NRXN, exhibited marked LA-MeA deficits. Chemogenetic activation of this circuit reversed these impaired social behaviors. These findings identify an amygdala circuit required to guide emotional responses to socially significant cues and identify an exploratory target for disorders associated with social impairments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.