ArticleNature immunology2017
The transcription factor musculin promotes the unidirectional development of peripheral T
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In one paragraph
Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Methylation profile of individuals with sickle cell trait.Epigenetics · 2025Pooled it
- Ambient PMEnvironment & health (Washington, D.C.) · 2026Article
- Musculin enhances the immune function of peritoneal macrophages in mice.Central-European journal of immunology · 2026Article
- Construction of a prognostic model for hepatocellular carcinoma based on necrosis by sodium overload-related genes and identification of ANKRD13B as a new prognostic marker.Functional & integrative genomics · 2025Article
- Single-cell RNA sequencing reveals the role of GTF2F2 in ovarian cancer oncogenesis and progression.Journal of ovarian research · 2025Article
- Mutual exclusivity and co-occurrence patterns of immune checkpoints indicate NKG2A relates to anti-PD-1 resistance in gastric cancer.Journal of translational medicine · 2024Article
- Matrine Ameliorates DSS-Induced Colitis by Suppressing Inflammation, Modulating Oxidative Stress and Remodeling the Gut Microbiota.International journal of molecular sciences · 2024Article
- Cathepsin W restrains peripheral regulatory T cells for mucosal immune quiescence.Science advances · 2023Article
- Cellular nanovesicles for therapeutic immunomodulation: A perspective on engineering strategies and new advances.Acta pharmaceutica Sinica. B · 2023Review
- Distinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential.Communications biology · 2023Article
- Cytokine storm and targeted therapy in hemophagocytic lymphohistiocytosis.Immunologic research · 2022Review
- Mesenchymal stromal cells-derived small extracellular vesicles modulate DC function to suppress Th2 responses via IL-10 in patients with allergic rhinitis.European journal of immunology · 2022Article
- Transcription Factor RUNX3 Mediates Plasticity of ThGM Cells Toward Th1 Phenotype.Frontiers in immunology · 2022Article
- Umbilical Cord Mesenchymal Stem Cells for Inhibiting the Fibrosis and Autoimmune Development in HOCl-Induced Systemic Scleroderma Mouse Model.International journal of stem cells · 2021Article
- RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition.Biology open · 2021Article
- The Pathogenic Roles of IL-22 in Colitis: Its Transcription Regulation by Musculin in T Helper Subsets and Innate Lymphoid Cells.Frontiers in immunology · 2021Article
- SATB1-mediated chromatin landscape in T cells.Nucleus (Austin, Tex.) · 2020Review
- Musculin Deficiency Aggravates Colonic Injury and Inflammation in Mice with Inflammatory Bowel Disease.Inflammation · 2020Article
- Antitumor Potency of an Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, Lisocabtagene Maraleucel in Combination With Ibrutinib or Acalabrutinib.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2020Article
- Transcriptomic changes and potential regulatory mechanism of intrauterine human chorionic gonadotropin co-cultured with peripheral blood mononuclear cells infusion in mice with embryonic implantation dysfunction.Annals of translational medicine · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Chuan WuEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Zuojia ChenEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Valerie DardalhonEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Sheng XiaoEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Theresa ThalhamerEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Mengyang LiaoDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Asaf MadiEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Rafael F FrancaEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Timothy HanEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Mohammed OukkaCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
Vijay KuchrooEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Brigham and Women's Hospital · USHarvard University · USSeattle Children's Hospital · US
Funding
Role of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI David A. Hafler · 1996 to 2026
$51.7MTransgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHARPE, ARLENE H. · 2003 to 2023
$42.5MTransgenic / Knock-out mouse coreP01AI073748 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BEHAR, SAMUEL M · 2008 to 2019
$17.1MRole of Th1 specific cell surface molecule Tim-3 in EAE.R01NS045937 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHROO, VIJAY K. · 2003 to 2016
$4.9MT CELL RESPONSE TO MYELIN PROTEOLIPID PROTEINR01NS030843 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHROO, VIJAY K. · 1998 to 2019
$4.1MThe role of Tim-1 in immune regulation and autoimmunityK01DK090105 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI XIAO, SHENG · 2011 to 2015
$796kRole of Dock8 in EAER21AI124735 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI OUKKA, MOHAMED · 2016 to 2017
$530kMolecular signatures of high salt induced pathogenic T cellsR00AI110649 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WU, CHUAN · 2015 to 2016
$498kMolecular signatures of high salt induced pathogenic T cellsK99AI110649 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WU, CHUAN · 2014 to 2014
$111kNIAID NIH HHS K99 AI110649NIAID NIH HHS P01 AI039671NIAID NIH HHS P01 AI056299NIAID NIH HHS P01 AI073748NIAID NIH HHS R00 AI110649NIAID NIH HHS R21 AI124735NIDDK NIH HHS K01 DK090105NINDS NIH HHS R01 NS030843NINDS NIH HHS R01 NS045937
Abstract
Although master transcription factors (TFs) are key to the development of specific T cell subsets, whether additional transcriptional regulators are induced by the same stimuli that dominantly repress the development of other, non-specific T cell lineages has not been fully elucidated. Through the use of regulatory T cells (T
Indexed as
Cell DifferentiationInflammationAnimalsBasic Helix-Loop-Helix ProteinsCells, CulturedForkhead Transcription FactorsGATA3 Transcription FactorGene Expression RegulationIntestinal MucosaMiceMice, Inbred C57BLMice, KnockoutPneumoniaTh2 CellsT-Lymphocytes, RegulatoryTranscription FactorsBasic Helix-Loop-Helix ProteinsForkhead Transcription FactorsFoxp3 protein, mouseGata3 protein, mouseGATA3 Transcription FactorMsc protein, mouseTranscription FactorsTransforming Growth Factor beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.