Evidence map›Paper›PMID 28114186›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2017

Pediatric HIV Disclosure Intervention Improves Knowledge and Clinical Outcomes in HIV-Infected Children in Namibia.

Kristin M Beima-Sofie, Laura Brandt, Ndapewa Hamunime, Mark Shepard, James Uusiku, Grace C John-Stewart, Gabrielle OʼMalley

Open access · hybridAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 76 citations in OpenAlex.

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  20. Optimizing Disclosure of HIV Status to a Diverse Population of HIV-Positive Youth at an Urban Pediatric HIV Clinic.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Kristin M Beima-Sofie*Department of Global Health, University of Washington, Seattle, WA; †International Training and Education Center for Health-Namibia, Windhoek, Namibia; ‡Namibian Ministry of Health and Social Services, Windhoek, Namibia; Departments of §Medicine; ‖Pediatrics; ¶Epidemiology, University of Washington, Seattle, WA; and #International Training and Education Center for Health, University of Washington, Seattle, WA.
Laura Brandt
Ndapewa Hamunime
Mark Shepard
James Uusiku
Grace C John-Stewart
Gabrielle OʼMalley
University of Washington · USMinistry of Health and Social Services · NA

Funding

Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
Evaluation of an Intervention to Support HIV Disclosure to Children in NamibiaR21HD074071 · NICHD · UNIVERSITY OF WASHINGTON · PI O'MALLEY, GABRIELLE · 2012 to 2013
$305k
NICHD NIH HHS K24 HD054314NICHD NIH HHS R21 HD074071
6 · The paper itself

Abstract

objectivesUsing routinely collected data, we evaluated a nationally implemented intervention to assist health care workers and caregivers with HIV disclosure to children. We assessed the impact of the intervention on child's knowledge and health outcomes.

methodsData were abstracted from national databases and patient charts for HIV-infected children aged 7-15 years attending 4 high-volume HIV clinics in Namibia. Disclosure rates, time to disclosure, and HIV knowledge in 314 children participating in the intervention were analyzed. Logistic regression was used to identify correlates of partial vs. full disclosure. Paired t-tests and McNemar tests were used to compare adherence and viral load (VL) before versus after intervention enrollment.

resultsAmong children who participated in the disclosure intervention, 11% knew their HIV status at enrollment and an additional 38% reached full disclosure after enrollment. The average time to full disclosure was 2.5 years (interquartile range: 1.2-3 years). Children who achieved full disclosure were more likely to be older, have lower VLs, and have been enrolled in the intervention longer. Among children who reported incorrect knowledge regarding why they take their medicine, 83% showed improved knowledge after the intervention, defined as knowledge of HIV status or adopting intervention-specific language. On comparing 0-12 months before vs. 12-24 months after enrollment in the intervention, VL decreased by 0.5 log10 copies per milliliter (N = 42, P = 0.004), whereas mean adherence scores increased by 10% (N = 88, P value < 0.001).

conclusionsThis HIV disclosure intervention demonstrated improved viral suppression, adherence, and HIV knowledge and should be considered for translation to other settings.

Indexed as

DisclosureHealth Knowledge, Attitudes, PracticeAdolescentChildFemaleHIV InfectionsHumansMaleMedication AdherenceNamibiaTreatment OutcomeViral Load

Identifiers

PMID28114186
PMCPMC5388570
OpenAlexW2571745147

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.