Evidence map›Paper›PMID 28113001›Full record

ArticleCell cycle (Georgetown, Tex.)2017

In vitro effects of tetraiodothyroacetic acid combined with X-irradiation on basal cell carcinoma cells.

John T Leith, Paul J Davis, Shaker A Mousa, Aleck A Hercbergs

Open access · bronzeAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Actions of Thyroid Hormones on Thyroid Cancers.Frontiers in endocrinology · 2021
    Review
  3. Delineating cell behavior and metabolism of non-melanoma skin cancer in vitro.In vitro cellular & developmental biology. Animal · 2020
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

John T Leitha Rhode Island Nuclear Science Center , Narragansett , RI, USA.
Paul J Davisb Albany Medical College , Albany , NY , USA.
Shaker A Mousac Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences , Rensselaer , NY , USA.
Aleck A Hercbergsd Cleveland Clinic , Cleveland , OH , USA.
Albany College of Pharmacy and Health Sciences · USAlbany Medical Center Hospital · USCleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated radiosensitization in an untreated basal cell carcinoma (TE.354.T) cell line and post-pretreatment with tetraiodothyroacetic acid (tetrac) X 1 h at 37°C, 0.2 and 2.0 µM tetrac. Radioresistant TE.354.T cells were grown in modified medium containing fibroblast growth factor-2, stem cell factor-1 and a reduced calcium level. We also added reproductively inactivated (30 Gy) "feeder cells" to the medium. The in vitro doubling time was 34.1 h, and the colony forming efficiency was 5.09 percent. These results were therefore suitable for clonogenic radiation survival assessment. The 250 kVp X-ray survival curve of control TE.354.T cells showed linear-quadratic survival parameters of α

Indexed as

Basal Cell CarcinomaCell DeathCell Line, TumorCell ProliferationCell SurvivalDNA Breaks, Double-StrandedDNA RepairDose-Response Relationship, RadiationFemaleHistonesHumansRadiation InjuriesThyroxineTumor Stem Cell AssayX-RaysH2AX protein, humanHistonestetraiodothyroacetic acidThyroxinebasal cell carcinomadouble-strand breaksradiation therapytetractetraiodothyroacetic acid

Identifiers

PMID28113001
PMCPMC5324738
OpenAlexW2582368740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.