Evidence map›Paper›PMID 28112995›Full record

ReviewNucleus (Austin, Tex.)2017

Nuclear membrane stretch and its role in mechanotransduction.

Balázs Enyedi, Philipp Niethammer

Abstract readReview
In one paragraph

Review in Nucleus (Austin, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

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  17. Review
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  20. Mechanical Forces in Nuclear Organization.Cold Spring Harbor perspectives in biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Balázs Enyedib Heart and Vascular Center , Semmelweis University , Budapest , Hungary.
Philipp Niethammera Cell Biology Program , Memorial Sloan Kettering Cancer Center , New York , NY , USA.

Funding

Regulation of Wound Detection in Animal TissuesR01GM099970 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI NIETHAMMER, PHILIPP MICHAEL · 2012 to 2020
$3.2M
NIGMS NIH HHS R01 GM099970
6 · The paper itself

Abstract

Most research in nuclear mechanotransduction has focused on the nuclear lamina and lamin binding proteins. These structures provide mechanical stability to the nucleus, establish a link between the cytoskeleton and chromatin, and can transmit mechanical signals. At the same time, mechanical perturbations to the nucleus also affect its phospholipid membranes. In this commentary, we discuss how changes in nuclear membrane tension can mediate mechanotransduction.

Indexed as

Mechanical PhenomenaMechanotransduction, CellularAnimalsCell NucleusHumansIntracellular Membranescell lysiscell swellingcPLinflammatory signalsmechanosensingmembrane tensionnuclear envelope

Identifiers

PMID28112995
PMCPMC5403133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.