Evidence map›Paper›PMID 28112948›Full record

ArticleJournal of proteome research2017

Mass-Spectrometry-Based Method To Quantify in Parallel Tau and Amyloid β 1-42 in CSF for the Diagnosis of Alzheimer's Disease.

Gwënaël Pottiez, Li Yang, Tessandra Stewart, Ning Song, Patrick Aro, Douglas R Galasko, Joseph F Quinn, Elaine R Peskind, Min Shi, Jing Zhang

Open access · greenAbstract read
In one paragraph

Article in Journal of proteome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Gwënaël PottiezDepartment of Pathology, School of Medicine, University of Washington , Seattle, Washington 98104, United States.ORCID 0000-0001-8485-4510
Li YangDepartment of Pathology, School of Medicine, University of Washington , Seattle, Washington 98104, United States.
Tessandra StewartDepartment of Pathology, School of Medicine, University of Washington , Seattle, Washington 98104, United States.
Ning SongDepartment of Pathology, School of Medicine, University of Washington , Seattle, Washington 98104, United States.
Patrick AroDepartment of Pathology, School of Medicine, University of Washington , Seattle, Washington 98104, United States.
Douglas R GalaskoDepartment of Neurosciences, University of California at San Diego , San Diego, California 92093, United States.
Joseph F QuinnDepartment of Neurology, Oregon Health and Science University , Portland, Oregon 97239, United States.
Elaine R PeskindNorthwest Network VISN-20 Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System , Seattle, Washington 98108, United States.
Min ShiDepartment of Pathology, School of Medicine, University of Washington , Seattle, Washington 98104, United States.
Jing ZhangDepartment of Pathology, School of Medicine, University of Washington , Seattle, Washington 98104, United States.
University of Washington · USOregon Health & Science University · USUniversity of California San Diego · US

Funding

THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
Outreach, Recruitment and Education CoreP30AG008017 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI DODGE, HIROKO HAYAMA · 1990 to 2019
$27.7M
Large Scale Biomarker Discovery and Validation for Parkinsons DiseaseU01NS082137 · NINDS · UNIVERSITY OF WASHINGTON · PI ZHANG, JING · 2012 to 2016
$6.0M
Peptide Biomarkers for Parkinson DiseaseU01NS091272 · NINDS · UNIVERSITY OF WASHINGTON · PI SHI, MIN · 2016 to 2020
$2.1M
Interaction of alpha-synuclein and neurotoxicants with Mac1-NADPH oxidaseR01ES019277 · NIEHS · UNIVERSITY OF WASHINGTON · PI ZHANG, JING · 2011 to 2015
$2.0M
Microglial Phox Activity In Parkinson's DiseaseR01ES016873 · NIEHS · UNIVERSITY OF WASHINGTON · PI ZHANG, JING · 2010 to 2014
$1.7M
NIA NIH HHS P30 AG008017NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005136NIEHS NIH HHS R01 ES016873NIEHS NIH HHS R01 ES019277NINDS NIH HHS U01 NS082137NINDS NIH HHS U01 NS091272
6 · The paper itself

Abstract

Alzheimer's disease (AD), the most common form of dementia, afflicts about 50 million people worldwide. Currently, AD diagnosis is primarily based on psychological evaluation and can only be confirmed post-mortem. Reliable and objective biomarkers for prognosis and diagnosis have been sought for years. Together, tau and amyloid β 1-42 (Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBiomarkersCase-Control StudiesHumansMass SpectrometryPeptide FragmentsROC CurveSensitivity and SpecificitySeverity of Illness Indextau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersPeptide Fragmentstau ProteinsAlzheimer’s diseaseamyloid βAβ42biomarkercerebrospinal fluiddiagnosismass spectrometrySRMtau

Identifiers

PMID28112948
PMCPMC5679294
OpenAlexW2580679988

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.