Evidence map›Paper›PMID 28112862›Full record

ArticleMagnetic resonance in medicine2017

Diffusion-compensated tofts model suggests contrast leakage through aneurysm wall.

Charles G Cantrell, Parmede Vakil, Yong Jeong, Sameer A Ansari, Timothy J Carroll

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Intracranial vessel wall lesions on MRI: anatomical and pathological issues.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Charles G CantrellNorthwestern University, Department of Biomedical Engineering, Evanston, Illinois, USA.
Parmede VakilUniversity of Illinois, College of Medicine, Chicago, Illinois, USA.
Yong JeongNorthwestern University, Department of Biomedical Engineering, Evanston, Illinois, USA.
Sameer A AnsariNorthwestern University, Department of Radiology, Evanston, Illinois, USA.
Timothy J CarrollUniversity of Chicago, Department of Radiology, Chicago, Illinois, USA.
Northwestern University · USUniversity of Illinois Chicago · USIllinois College · US

Funding

Development of Novel MR Imaging for Ischemic Stroke EvaluationR01NS093908 · NINDS · UNIVERSITY OF CHICAGO · PI CARROLL, TIMOTHY J, CHRISTOFORIDIS, GREGORY · 2015 to 2019
$2.6M
Time Resolved MRA of the Intracranial VasculatureR01HL088437 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CARROLL, TIMOTHY J · 2008 to 2011
$1.5M
High Resolution and Functional MRI Assessment of Intracranial Atherosclerotic PlaqueR21HL130969 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ANSARI, SAMEER A · 2016 to 2017
$425k
Development of MRI-based Cerebral Oxygen Extraction FractionR21EB017928 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CARROLL, TIMOTHY J · 2014 to 2015
$424k
NHLBI NIH HHS R01 HL088437NHLBI NIH HHS R21 HL130969NIBIB NIH HHS R21 EB017928NINDS NIH HHS R01 NS093908
6 · The paper itself

Abstract

purposeThe purpose of this study was to investigate the diffusional transport of contrast agent and its effects on kinetic modeling of dynamic contrast enhanced (DCE) images.

methodsWe performed simulations of our diffusion-compensated model and compared these results to human intracranial aneurysms (IAs). We derive an easy-to-use parameterization of diffusional effects that can provide an accurate estimate of diffusion corrected contrast agent leakage rates (k

resultsProbability distributions of simulated versus measured data show contrast leakage away from the aneurysm wall. Parameterization of diffusional effects on k

conclusionsWe report the first evidence of diffusion-compensated permeability modeling in intracranial aneurysms and propose a parameterization of diffusional effects on k

Indexed as

Diffusion Magnetic Resonance ImagingAdultAgedAged, 80 and overAneurysmComputer SimulationContrast MediaFemaleHumansImage Processing, Computer-AssistedIntracranial AneurysmKineticsMaleMiddle AgedModels, StatisticalMultivariate AnalysisContrast Mediaaneurysmcontrast leakagerupture riskTofts model

Identifiers

PMID28112862
PMCPMC5808924
OpenAlexW2582187591

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.