ArticleNature microbiology2017
Global and regional dissemination and evolution of Burkholderia pseudomallei.
Article in Nature microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
116 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Whole Genome Sequencing and Comparative Genomics of the Emerging PathogenPathogens (Basel, Switzerland) · 2025Pooled it
- Diagnostic accuracy of non-culture methods for the diagnosis of melioidosis: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- CRISPR-based environmental detection of Burkholderia pseudomallei identifies sanitation gaps and melioidosis risk in northeast Thailand.Nature communications · 2026Article
- Article
- Melioidosis imported to Northern Germany: a case report series.Infection · 2026Article
- Global dispersal of Burkholderia pseudomallei and the evolving endemicity of melioidosis in the United States of America.PLoS neglected tropical diseases · 2026Review
- Global animal melioidosis prevalence: a systematic review and meta-analysis.Irish veterinary journal · 2026Article
- Molecular epidemiological analysis ofFrontiers in public health · 2026Article
- The Hidden Threat: Polyarticular Septic Arthritis Unmasking Disseminated Melioidosis.Journal of orthopaedic case reports · 2026Article
- Laboratory diagnosis of melioidosis.PLoS neglected tropical diseases · 2025Review
- Whole genome study and construction of SHERLOCK detection method for endemic strains ofMicrobiology spectrum · 2025Article
- Synovial Fluid Analysis in Melioidosis: Experiences from the Darwin Prospective Melioidosis Study.Pathogens (Basel, Switzerland) · 2025Article
- Detection of Burkholderia thailandensis in Soil Samples, Suriname.Emerging infectious diseases · 2025Article
- Melioidosis in Asia-Pacific Nations: Expanding Boundaries but Unknowns Remain.Respirology (Carlton, Vic.) · 2025Article
- Proteomic-based identification of novel EV-derived protein antibodies biomarkers for melioidosis diagnosis.PLoS neglected tropical diseases · 2025Article
- Overcoming research challenges in resource-limited settings: perspectives from Thailand.Nature reviews. Microbiology · 2025Article
- Risk Assessment of Global Animal Melioidosis Under Current and Future Climate Scenarios.Animals : an open access journal from MDPI · 2025Article
- Burkholderia pseudomallei Sequence Type 46 Transmission from Asia to Australia.Emerging infectious diseases · 2025Article
- Hemophagocytic Lymphohistiocytosis Secondary to Melioidosis in Paediatric Patients: A Case Series.Infection and drug resistance · 2025Article
- Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
Abstract
The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.
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Registered trials
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