ReviewActa bio-medica : Atenei Parmensis2016
Learning more and spending less with neglected laboratory parameters: the paradigmatic case of red blood cell distribution width.
Review in Acta bio-medica : Atenei Parmensis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Red blood cell distribution width as a predictor of mortality in critically ill pediatric patients: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Red blood cell distribution width as a predictor of mortality and poor functional outcome after acute ischemic stroke: a meta-analysis and meta-regression.BMC neurology · 2024Pooled it
- Red Blood Cell Distribution Is a Significant Predictor of Severe Illness in Coronavirus Disease 2019.Acta haematologica · 2021Pooled it
- Association of the red cell distribution width to total serum calcium ratio with severe AKI in patients undergoing cardiac surgery: a retrospective cohort study using the MIMIC-IV database.Journal of cardiothoracic surgery · 2026Observational
- Article
- A study on predicted in-hospital mortality in critically ill patients with coronary heart disease: analysis of the MIMIC-IV database.BMC medical informatics and decision making · 2025Article
- Association between red cell distribution width and its ratio with albumin and diabetic nephropathy/retinopathy: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2025Review
- Red cell distribution width as a potential new biomarker to predict the clinical severity of acute diverticulitis.BMC gastroenterology · 2025Article
- Article
- Utilizing red blood cell distribution width (RDW) as a reliable biomarker to predict treatment effects after chimeric antigen receptor T cell therapy.Clinical and experimental medicine · 2024Article
- Article
- Red blood cell distribution width (RDW) is a significant predictor of survival in laryngeal cancer patients: Systematic literature review and meta-analysis.Journal of medical biochemistry · 2023Article
- Red Cell Distribution Width as a Prognostic Indicator in Acute Medical Admissions.Journal of clinical medicine · 2023Article
- [Red cell distribution width in the prognosis of surgical correction of congenital heart diseases].Archivos de cardiologia de Mexico · 2023Article
- Propensity score analysis of red cell distribution width to serum calcium ratio in acute myocardial infarction as a predictor of in-hospital mortality.Frontiers in cardiovascular medicine · 2023Article
- Differences in selected blood parameters between brachycephalic and non-brachycephalic dogs.Frontiers in veterinary science · 2023Article
- RDW shows prognostic potential in hospitalized patients with COVID-19.Journal of medical virology · 2022Article
- Implication of COVID-19 on Erythrocytes Functionality: Red Blood Cell Biochemical Implications and Morpho-Functional Aspects.International journal of molecular sciences · 2022Review
- Assessment of the association between red blood cell distribution width and disease activity in patients with systemic vasculitis.Experimental and therapeutic medicine · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to increasing shortage of public healthcare resources in many countries around the globe, the use of simple, rapid and inexpensive laboratory parameters may be seen as a valuable aid for preliminary and cost-effective risk stratification of patients. Anisocytosis, conventionally measured by hematologic analyzers as the red blood cell distribution width (RDW), is an index of the heterogeneity of erythrocytes volumes. Several lines of evidence now attest that increased RDW values are commonplace in patients with many disorders, especially in those with the most prevalent conditions such as cardiovascular disease, diabetes, cancer and infections. Although the nature of this association remains to be definitely disclosed, what is strongly emerging from the recent scientific research is that the RDW should now be regarded as a "non" innocent bystander, wherein anisocytosis may be an active player in the pathogenesis of many pathologies. Therefore, major attention should be placed on this inexpensive but clinically meaningful parameter. The recent finding that dynamic changes of RDW are strongly predictors of mortality also suggests that continuous monitoring of anisocytosis may be an ancillary useful tool for establishing the effectiveness of managed care, as well as for deciding whether or not the overall clinical status is improving.
Indexed as
Identifiers
28112703PMC10521889W2585614805What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.