ArticleJournal of pediatric gastroenterology and nutrition2017
Value of IgA tTG in Predicting Mucosal Recovery in Children With Celiac Disease on a Gluten-Free Diet.
Article in Journal of pediatric gastroenterology and nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Call for Research on the Prognostic Role of Follow-Up Histology in Celiac Disease: A Systematic Review.Frontiers in physiology · 2019Pooled it
- Micronutrient deficiencies in patients with celiac disease: A systematic review and meta-analysis.International journal of immunopathology and pharmacologyPooled it
- Low Levels of Detectable Urine and Stool GIPs in Children with Celiac Disease on a Gluten-Free Diet.JPGN reports · 2023Trial
- Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial.Gastroenterology · 2021Trial
- Subclinical Myocardial Dysfunction in Children and Adolescents with Celiac Disease: A Cross-Sectional Case-Control Study.Pediatric cardiology · 2026Article
- Central Asian-Mongolian-Iranian celiac disease taskforce: A look into the future- 2026-2035 and beyond.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Celiac Disease: A Comprehensive Review of Epidemiology, Pathogenesis, and Therapeutic Strategies.Digestive diseases and sciences · 2026Review
- Increased parotid microvascularity without stiffness differences in children with celiac disease.Pediatric radiology · 2026Article
- Guidelines for the management of coeliac disease: recommendations of the Intestinal Diseases Section of the Polish Society of Gastroenterology.Przeglad gastroenterologiczny · 2026Article
- Comparable disease course in pediatric celiac disease with or without endoscopic confirmation at high anti-TG2-IgA-antibody titers.Frontiers in nutrition · 2026Article
- Determinants of adherence to gluten-free diet in children with celiac disease and the impact of counseling by trained dietician on adherence.JPGN reports · 2025Article
- Neighborhood Socioeconomic Deprivation Associates with Decreased Serologic Normalization Rates in Pediatric Celiac Disease.The Journal of pediatrics · 2025Article
- Measuring the Risk of Gluten Exposure: Development of the Gluten Exposure Risk Assessment in Pediatric Patients.The American journal of gastroenterology · 2025Article
- Limitations of Faecal Calprotectin in Detecting Histological Changes and Persistent Villous Atrophy in Patients With Coeliac Disease on a Gluten-Free Diet.Alimentary pharmacology & therapeutics · 2025Article
- No-Biopsy Diagnosis of Coeliac Disease in Children Without Anti-Endomysial IgA Antibody Testing: Combining Anti-Tissue Transglutaminase IgA and Anti-Deamidated Gliadin IgG Antibodies.Journal of paediatrics and child health · 2025Article
- Parameters associated with the development of autoimmune diseases in pediatric onset celiac disease.European journal of pediatrics · 2025Article
- Vitamins and Celiac Disease: Beyond Vitamin D.Metabolites · 2025Review
- Impact of ESPGHAN no-biopsy strategy on the outcome of celiac disease treatment in children.Frontiers in pediatrics · 2025Article
- Prevalence of acute reactions to gluten contamination of the diet in children with celiac disease.Frontiers in pediatrics · 2025Article
- Gluten-Free Diet Adherence Evaluation in Adults with Long-Standing Celiac Disease.Foods (Basel, Switzerland) · 2024Article
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Abstract
objectivesOur objective was to determine the rate of mucosal recovery in pediatric patients with celiac disease on a gluten-free diet. We also sought to determine whether immunoglobulin A tissue transglutaminase (tTG) correlates with mucosal damage at the time of a repeat endoscopy with duodenal biopsy in these patients.
methodsWe performed a retrospective chart review of 103 pediatric patients, younger than 21 years, with a diagnosis of celiac disease defined as Marsh 3 histology, and who underwent a repeat endoscopy with duodenal biopsy at least 12 months after initiating a gluten-free diet.
resultsWe found that 19% of pediatric patients treated with a gluten-free diet had persistent enteropathy. At the time of the repeat biopsy, tTG was elevated in 43% of cases with persistent enteropathy and 32% of cases in which there was mucosal recovery. Overall the positive predictive value of the autoantibody tTG was 25% and the negative predictive value was 83% in patients on a gluten-free diet for a median of 2.4 years.
conclusionsNearly 1 in 5 children with celiac disease in our population had persistent enteropathy despite maintaining a gluten-free diet and immunoglobulin A tTG was not an accurate marker of mucosal recovery. Neither the presence of symptoms nor positive serology were predictive of a patient's histology at the time of repeat biopsy. These findings suggest a revisitation of monitring and management criteria of celiac disease in childhood.
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