ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017
Intraoperative multi-exposure speckle imaging of cerebral blood flow.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- DASHING-LSCI: deep learning-based anatomical multiclass segmentation for human intraoperative neurosurgical guidance - laser speckle contrast imaging.Biomedical optics express · 2026Article
- Time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow response to intracranial pressure elevation.Journal of biomedical optics · 2026Article
- Article
- Physics-informed neural network for mapping vascular and tissue dynamics using laser speckle contrast imaging.Neurophotonics · 2026Article
- Mapping fast tissue dynamics with long camera exposures via intensity modulation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Time-Resolved Laser Speckle Contrast Imaging (TR-LSCI) of Cerebral Blood Flow Response to Intracranial Pressure Elevation.bioRxiv : the preprint server for biology · 2026Article
- Advanced optical phantom mimicking microvascular and directed blood flow in mouse brain.Biomedical engineering letters · 2026Article
- Endoscopic laser speckle imaging enables real-time prediction of parathyroid function in thyroidectomy.Lasers in medical science · 2025Article
- Advancing intraoperative cerebral blood flow monitoring: integrating imaging photoplethysmography and laser speckle contrast imaging in neurosurgery.Frontiers of optoelectronics · 2025Article
- Article
- Realtime assessment of vascular occlusion and reperfusion in animal models of intraoperative imaging - a pilot study.Innovative surgical sciences · 2024Article
- Quantitative hemodynamic imaging: a method to correct the effects of optical properties on laser speckle imaging.Neurophotonics · 2023Article
- Projection mapping system for laser speckle contrast image: feasibility study for clinical application.Journal of biomedical optics · 2023Article
- Quasi-analytic solution for real-time multi-exposure speckle imaging of tissue perfusion.Biomedical optics express · 2023Article
- A quasi-analytic solution for real-time multi-exposure speckle imaging of tissue perfusion.bioRxiv : the preprint server for biology · 2023Article
- Using pressure-driven flow systems to evaluate laser speckle contrast imaging.Journal of biomedical optics · 2023Article
- Feasibility and comparison of laparoscopic laser speckle contrast imaging to near-infrared display of indocyanine green in intraoperative tissue blood flow/tissue perfusion in preclinical porcine models.Surgical endoscopy · 2023Article
- All fiber-based illumination system for multi-exposure speckle imaging.Biomedical optics express · 2023Article
- Continuous blood flow visualization with laser speckle contrast imaging during neurovascular surgery.Neurophotonics · 2022Article
- Synthetic exposure with a CMOS camera for multiple exposure speckle imaging of blood flow.Scientific reports · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
Multiple studies have demonstrated that laser speckle contrast imaging (LSCI) has high potential to be a valuable cerebral blood flow monitoring technique during neurosurgery. However, the quantitative accuracy and sensitivity of LSCI is limited, and highly dependent on the exposure time. An extension to LSCI called multi-exposure speckle imaging (MESI) overcomes these limitations, and was evaluated intraoperatively in patients undergoing brain tumor resection. This clinical study ( n = 8) recorded multiple exposure times from the same cortical tissue area spanning 0.5-20 ms, and evaluated images individually as single-exposure LSCI and jointly using the MESI model. This study demonstrated that the MESI estimates provided the broadest flow sensitivity for sampling the flow magnitude in the human brain, closely followed by the shorter exposure times. Conservation of flow analysis on vascular bifurcations was used to validate physiological accuracy, with highly conserved flow estimates (<10%) from both MESI and 1 ms LSCI ( n = 14 branches). The MESI model had high goodness-of-fit with proper image calibration and acquisition, and was used to monitor blood flow changes after tissue cautery. Results from this study demonstrate that intraoperative MESI can be performed with high quantitative accuracy and sensitivity for cerebral blood flow monitoring.
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