ArticleHuman brain mapping2017
Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07789938 (Intraoperative Monitoring of Motor, Visual and Cortico-cortical Evoked Potentials in Brain Tumor Surgery Under General Anesthesia), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intraoperative Monitoring of Motor, Visual and Cortico-cortical Evoked Potentials in Brain Tumor Surgery Under General Anesthesia: Prospective Cohort Studies
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Methodologies to detect cortico-cortical evoked potentials: a systematic review.Frontiers in human neuroscience · 2025Pooled it
- An update on tests used for intraoperative monitoring of cognition during awake craniotomy.Acta neurochirurgica · 2024Pooled it
- Neuromonitoring of the language pathways using cortico-cortical evoked potentials: a systematic review and meta-analysis.Neurosurgical review · 2022Pooled it
- Utility and limitations of cortico-cortical evoked potentials in pediatric resective epilepsy surgery: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Arcuate fasciculus cortico-cortical and axono-cortical evoked potentials with post-resection excitability changes in perisylvian glioma.Clinical neurophysiology practice · 2026Article
- Review
- Single pulse electrical stimulation of the medial thalamic surface induces narrower high gamma band activities in the sensorimotor cortex.Scientific reports · 2025Article
- ER-detect: A pipeline for robust detection of early evoked responses in BIDS-iEEG electrical stimulation data.Journal of neuroscience methods · 2025Article
- Intraoperative Language Area Mapping: Cortico-Cortical Evoked Potential.Brain tumor research and treatment · 2025Review
- Subcallosal cingulate deep brain stimulation evokes two distinct cortical responses via differential white matter activation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- ER-detect: a pipeline for robust detection of early evoked responses in BIDS-iEEG electrical stimulation data.bioRxiv : the preprint server for biology · 2024Article
- The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond.Frontiers in human neuroscience · 2024Review
- Free-water correction DTI-based tractography in brain tumor surgery: assessment with functional and electrophysiological mapping of the white matter.Acta neurochirurgica · 2023Article
- Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging for Language Mapping in Brain Tumor Surgery: Validation With Direct Cortical Stimulation and Cortico-Cortical Evoked Potential.Korean journal of radiology · 2023Article
- Identifying subcortical connectivity during brain tumor surgery: a multimodal study.Brain structure & function · 2023Article
- Changes in Distributed Motor Network Connectivity Correlates With Functional Outcome After Surgical Resection of Brain Tumors.Neurosurgery practice · 2023Article
- Structural networking of the developing brain: from maturation to neurosurgical implications.Frontiers in neuroanatomy · 2023Review
- Mapping effective connectivity of human amygdala subdivisions with intracranial stimulation.Nature communications · 2022Article
- Functional Approaches to the Surgery of Brain Gliomas.Advances and technical standards in neurosurgery · 2022Review
- Time-frequency signatures evoked by single-pulse deep brain stimulation to the subcallosal cingulate.Frontiers in human neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to preserve postoperative language function, we recently proposed a new intraoperative method to monitor the integrity of the dorsal language pathway (arcuate fasciculus; AF) using cortico-cortical evoked potentials (CCEPs). Based on further investigations (20 patients, 21 CCEP investigations), including patients who were not suitable for awake surgery (five CCEP investigations) or those without preoperative neuroimaging data (eight CCEP investigations including four with untraceable tractography due to brain edema), we attempted to clarify the clinical impact of this new intraoperative method. We monitored the integrity of AF by stimulating the anterior perisylvian language area (AL) by recording CCEPs from the posterior perisylvian language area (PL) consecutively during both general anesthesia and awake condition. After tumor resection, single-pulse electrical stimuli were also applied to the floor of the removal cavity to record subcortico-cortical evoked potentials (SCEPs) at AL and PL in 12 patients (12 SCEP investigations). We demonstrated that (1) intraoperative dorsal language network monitoring was feasible even when patients were not suitable for awake surgery or without preoperative neuroimaging studies, (2) CCEP is a dynamic marker of functional connectivity or integrity of AF, and CCEP N1 amplitude could even become larger after reduction of brain edema, (3) a 50% CCEP N1 amplitude decline might be a cut-off value to prevent permanent language dysfunction due to impairment of AF, (4) a correspondence (<2.0 ms difference) of N1 onset latencies between CCEP and the sum of SCEPs indicates close proximity of the subcortical stimulus site to AF (<3.0 mm). Hum Brain Mapp 38:1977-1991, 2017. © 2017 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.