Evidence map›Paper›PMID 28112425›Full record

ArticleParasite immunology2017

In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani.

N H Manamperi, S Oghumu, N Pathirana, M V C de Silva, W Abeyewickreme, A R Satoskar, N D Karunaweera

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasite immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. An Insight Into Systemic Immune Response inFrontiers in immunology · 2021
    Trial
  2. Article
  3. Proteome profiling of cutaneous leishmaniasis lesions due to dermotropicbioRxiv : the preprint server for biology · 2024
    Article
  4. Article
  5. Diagnostic Tools for Cutaneous Leishmaniasis Caused byDiagnostics (Basel, Switzerland) · 2023
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Histopathology of Cutaneous Leishmaniasis Caused byBioMed research international · 2020
    Article
  11. Article
  12. Article
  13. Immunopathology of Cutaneous Leishmaniasis in a Cohort of Sri Lankan Patients.Clinical pathology (Thousand Oaks, Ventura County, Calif.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

N H ManamperiFaculty of Medicine, Department of Parasitology, University of Kelaniya, Ragama, Sri Lanka.
S OghumuDepartment of Environmental Health Sciences, College of Public Health, Ohio State University, Columbus, OH, USA.
N PathiranaDepartment of Dermatology, Army Hospital, Colombo, Sri Lanka.
M V C de SilvaFaculty of Medicine, Department of Pathology, University of Colombo, Colombo, Sri Lanka.
W AbeyewickremeFaculty of Medicine, Department of Parasitology, University of Kelaniya, Ragama, Sri Lanka.
A R SatoskarDepartment of Pathology, Wexner Medical Center, Ohio State University, Columbus, OH, USA.
N D KarunaweeraFaculty of Medicine, Department of Parasitology, University of Colombo, Colombo, Sri Lanka.ORCID 0000-0003-3985-1817
University of Colombo · LKUniversity of Kelaniya · LKLanka Hospitals · LKOhio Department of Health · USThe Ohio State University Wexner Medical Center · US

Funding

Epidemiology and transmission of Leishmania donovani infections in Sri Lanka and BhutanU01AI136033 · NIAID · UNIVERSITY OF COLOMBO · PI KARUNAWEERA, NADIRA DHARSHANI, ZHOU, GUOFA · 2017 to 2021
$2.0M
Study of cutaneous leishmaniasis in Sri Lanka caused by L.donovaniR01AI099602 · NIAID · UNIVERSITY OF COLOMBO · PI KARUNAWEERA, NADIRA DHARSHANI · 2012 to 2016
$635k
NIAID NIH HHS R01 AI099602NIAID NIH HHS U01 AI136033
6 · The paper itself

Abstract

Cutaneous leishmaniasis in Sri Lanka is a newly established parasitic disease caused by the usually visceralizing Leishmania donovani. Skin lesions manifest as non-itchy, non-tender papules, nodules or ulcers. In situ cytokine expression provides clues for immunopathogenesis of this localized form of disease. Skin biopsies from 58 patients were analyzed for histological appearance and in situ cytokine expression of T-helper 1 (Th1) and T-helper 2 (Th2) cytokines, namely interferon (IFN)-γ, interleukin (IL)-12A, tumor necrosis factor (TNF)-α, IL-4 and IL-10 by real-time RT-PCR. Significant up-regulation of the Th1 cytokine IFN-γ and down-regulation of the Th2 cytokine IL-4 were seen in patients compared to healthy controls. Significantly elevated tissue expression of IFN-γ and TNF-α was seen in lesions that presented later than 6 months from the time of onset, while IL-4 expression was more prominent in lesions that responded poorly to antimony therapy. A prominent Th1 response appears to support resolving of lesions, whereas a Th2-biased milieu tends to favor poor responsiveness to antimony and delayed lesion healing in L. donovani infections in Sri Lanka.

Indexed as

Leishmania donovaniAnimalsDown-RegulationFemaleHumansInterferon-gammaInterleukin-10Interleukin-4Leishmaniasis, CutaneousMaleTh1 CellsTh2 CellsTumor Necrosis Factor-alphaUp-RegulationIL10 protein, humanInterferon-gammaInterleukin-10Interleukin-4Tumor Necrosis Factor-alphacell-mediated immunityhistopathologyIFN-γIL-4Sri LankaTNF-α

Identifiers

PMID28112425
PMCPMC5354984
OpenAlexW2580008651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.