ArticleScientific reports2017
Regulation of genes related to immune signaling and detoxification in Apis mellifera by an inhibitor of histone deacetylation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Gut microbiota-derived butyrate primes systemic immunity in honey bees by mediating lipid metabolic reprogramming.Nature communications · 2026Article
- Insect immune systems: same same but different but still same.Frontiers in immunology · 2026Review
- Differential RNAi efficacy of siRNA and dsRNA targeting key genes for pest control inFrontiers in insect science · 2025Article
- Climate change-induced stress in the honey beeFrontiers in physiology · 2025Review
- Short-chain fatty acids: linking diet, the microbiome and immunity.Nature reviews. Immunology · 2024Review
- Invertebrate Immunity, Natural Transplantation Immunity, Somatic and Germ Cell Parasitism, and Transposon Defense.International journal of molecular sciences · 2024Review
- Differential bumble bee gene expression associated with pathogen infection and pollen diet.BMC genomics · 2023Article
- Parasite and Pesticide Impacts on the Bumblebee (International journal of molecular sciences · 2023Article
- Symbiotic Microorganisms and Their Different Association Types in Aquatic and Semiaquatic Bugs.Microbiology spectrum · 2022Article
- The Insecticide Imidacloprid DecreasesInsects · 2022Article
- Effect of amide protoporphyrin derivatives on immune response in Apis mellifera.Scientific reports · 2022Article
- Epigenetic regulations as drivers of insecticide resistance and resilience to climate change in arthropod pests.Frontiers in genetics · 2022Review
- Real-time monitoring of deformed wing virus-infected bee foraging behavior following histone deacetylase inhibitor treatment.iScience · 2021Article
- Review
- The novel insecticides flupyradifurone and sulfoxaflor do not act synergistically with viral pathogens in reducing honey bee (Apis mellifera) survival but sulfoxaflor modulates host immunocompetence.Microbial biotechnology · 2021Article
- Identification of Immune Regulatory Genes inInsects · 2020Article
- Sublethal effects of chronic exposure to CdO or PbO nanoparticles or their binary mixture on the honey bee (Apis millefera L.).Environmental science and pollution research international · 2020Article
- Snellenius manilae bracovirus suppresses the host immune system by regulating extracellular adenosine levels in Spodoptera litura.Scientific reports · 2020Article
- Novel probiotic approach to counter Paenibacillus larvae infection in honey bees.The ISME journal · 2020Article
- Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis.PloS one · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The western honeybee (Apis mellifera) is essential for the global economy due to its important role in ecosystems and agriculture as a pollinator of numerous flowering plants and crops. Pesticide abuse has greatly impacted honeybees and caused tremendous loss of honeybee colonies worldwide. The reasons for colony loss remain unclear, but involvement of pesticides and pathogen-pesticide interactions has been hypothesized. Histone deacetylase inhibitors (HDACis) inhibit the activity of histone acetylase, which causes the hyperacetylation of histone cores and influences gene expression. In this study, sodium butyrate, an HDACi, was used as a dietary supplement for honeybees; after treatment, gene expression profiles were analyzed using quantitative PCR. The results showed that sodium butyrate up-regulated genes involved in anti-pathogen and detoxification pathways. The bioassay results showed that honeybees treated with sodium butyrate were more tolerant to imidacloprid. Additionally, sodium butyrate strengthened the immune response of honeybees to invasions of Nosema ceranae and viral infections. We also performed a bioassay in which honeybees were exposed to pesticides and pathogens. Our results provide additional data regarding the mechanism by which honeybees react to stress and the potential application of HDACis in beekeeping.
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