Evidence map›Paper›PMID 28112260›Full record

ArticleScientific reports2017

An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage.

J H Southcombe, G Mounce, K McGee, A Elghajiji, J Brosens, S Quenby, T Child, I Granne

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Review
  7. Aberrant CD8Frontiers in immunology · 2024
    Article
  8. CD4Journal of immunology research · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Decidual CD8Journal of translational medicine · 2020
    Article
  16. Review
  17. Review
  18. Memory T Cells in Pregnancy.Frontiers in immunology · 2019
    Review
  19. Aging impacts CD103Aging cell · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

J H SouthcombeNuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3 Women's Centre, JR Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.
G MounceNuffield Department of Obstetrics and Gynaecology, Oxford Fertility and Institute of Reproductive Sciences, University of Oxford, Level 3 Women's Centre, JR Hospital, Headley Way, Headington, Oxford, OX4 2HW, UK.
K McGeeNuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3 Women's Centre, JR Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.
A ElghajijiNuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3 Women's Centre, JR Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.
J BrosensDivision of Biomedical Sciences, Clinical Science Research Laboratories, Warwick Medical School, University of Warwick, Coventry CV2 2DX, UK.
S QuenbyDivision of Biomedical Sciences, Clinical Science Research Laboratories, Warwick Medical School, University of Warwick, Coventry CV2 2DX, UK.
T ChildNuffield Department of Obstetrics and Gynaecology, Oxford Fertility and Institute of Reproductive Sciences, University of Oxford, Level 3 Women's Centre, JR Hospital, Headley Way, Headington, Oxford, OX4 2HW, UK.
I GranneNuffield Department of Obstetrics and Gynaecology, Oxford Fertility and Institute of Reproductive Sciences, University of Oxford, Level 3 Women's Centre, JR Hospital, Headley Way, Headington, Oxford, OX4 2HW, UK.
University of Oxford · GBOxford Fertility · GBUniversity of Warwick · GB

Funding

Medical Research Council MR/R014167/1
6 · The paper itself

Abstract

When trying to conceive 1% of couples have recurrent miscarriages, defined as three or more consecutive pregnancy losses. This is not accounted for by the known incidence of chromosomal aneuploidy in miscarriage, and it has been suggested that there is an immunological aetiology. The endometrial mucosa is populated by a variety of immune cells which in addition to providing host pathogen immunity must facilitate pregnancy. Here we characterise the endometrial CD8-T cell population during the embryonic window of implantation and find that the majority of cells are tissue resident memory T cells with high levels of CD69 and CD103 expression, proteins that prevent cells egress. We demonstrate that unexplained recurrent miscarriage is associated with significantly decreased expression of the T-cell co-receptor CD8 and tissue residency marker CD69. These cells differ from those found in control women, with less expression of CD127 indicating a lack of homeostatic cell control through IL-7 signalling. Nevertheless this population is resident in the endometrium of women who have RM, more than three months after the last miscarriage, indicating that the memory CD8-T cell population is altered in RM patients. This is the first evidence of a differing pre-pregnancy phenotype in endometrial immune cells in RM.

Indexed as

Immunologic MemoryAbortion, HabitualAdultCD8 AntigensCell SeparationEndometriumFemaleHumansInterferon-gammaLeukocyte Common AntigensLymphocyte ActivationPhenotypeT-LymphocytesCD8 AntigensInterferon-gammaLeukocyte Common Antigens

Identifiers

PMID28112260
PMCPMC5256279
OpenAlexW2582263041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.