ArticleScientific reports2017
Nanoscale Topography on Black Titanium Imparts Multi-biofunctional Properties for Orthopedic Applications.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.
- 3D-printed porous Ti6Al4V scaffolds for long bone repair in animal models: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Preparation methods, mechano-bactericidal performance and mechanisms of Ti-based nanostructure arrays: A review.Discover nano · 2026Review
- Nature-inspired biomaterial innovations to counter medical device-associated infections.Biomaterials science · 2026Review
- Designing a heterostructure of graphite-like layer/TaORegenerative biomaterials · 2026Article
- Comprehensive review of bacterial death mechanism on nanopillared nanostructured surfaces.Biophysical reviews · 2025Review
- The effect of the dual scale surface topography of a surface-modified titanium alloy on its bactericidal activity againstRSC advances · 2025Article
- Mechanobactericidal nanotopographies for food industry: A promising strategy for eradicating foodborne pathogens - progress and challenges.Journal of food and drug analysis · 2024Review
- Preferential adhesion of bacterial cells onto top- and bottom-mounted nanostructured surfaces under flow conditions.Nanoscale advances · 2023Article
- Progress in Nanostructured Mechano-Bactericidal Polymeric Surfaces for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2023Review
- Designing Effective Antimicrobial Nanostructured Surfaces: Highlighting the Lack of Consensus in the Literature.ACS omega · 2023Review
- Finite Element Modelling of a Gram-Negative Bacterial Cell and Nanospike Array for Cell Rupture Mechanism Study.Molecules (Basel, Switzerland) · 2023Article
- Nature-Inspired Surface Structures Design for Antimicrobial Applications.International journal of molecular sciences · 2023Review
- Multi-functional approach in the design of smart surfaces to mitigate bacterial infections: a review.Frontiers in cellular and infection microbiology · 2023Review
- Mechanotransduction in high aspect ratio nanostructured meta-biomaterials: The role of cell adhesion, contractility, and transcriptional factors.Materials today. Bio · 2022Article
- Eco-friendly bacteria-killing by nanorods through mechano-puncture with top selectivity.Bioactive materials · 2022Article
- Fluid Flow Induces Differential Detachment of Live and Dead Bacterial Cells from Nanostructured Surfaces.ACS omega · 2022Article
- Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges.Journal of functional biomaterials · 2022Review
- Bio-Inspired Nanostructured Ti-6Al-4V Alloy: The Role of Two Alkaline Etchants and the Hydrothermal Processing Duration on Antibacterial Activity.Nanomaterials (Basel, Switzerland) · 2022Article
- Scalable Hybrid Antibacterial Surfaces: TiOACS omega · 2022Article
- Medical high-entropy alloy: Outstanding mechanical properties and superb biological compatibility.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have developed a chlorine based reactive ion etching process to yield randomly oriented anisotropic nanostructures that render the titanium metal surface 'black' similar to that of black silicon. The surface appears black due to the nanostructures in contrast to the conventional shiny surface of titanium. The nanostructures were found to kill bacteria on contact by mechanically rupturing the cells as has been observed previously on wings of certain insects. The etching was optimized to yield nanostructures of ≈1 μm height for maximal bactericidal efficiency without compromising cytocompatibility. Within 4 hours of contact with the black titanium surface, 95% ± 5% of E. coli, 98% ± 2% of P. aeruginosa, 92% ± 5% of M. smegmatis and 22% ± 8% of S. aureus cells that had attached were killed. The killing efficiency for the S. aureus increased to 76% ± 4% when the cells were allowed to adhere up to 24 hours. The black titanium supported the attachment and proliferation of human mesenchymal stem cells and augmented osteogenic lineage commitment in vitro. Thus, the bioinspired nanostructures on black titanium impart multi-biofunctional properties toward engineering the next-generation biomaterials for orthopedic implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.