ArticleScientific reports2017
Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.
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Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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28citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry.Blood advances · 2020Pooled it
- Multiple myeloma with concomitant chronic lymphocytic leukemia: evidence for independent clonal origin.Leukemia · 2026Article
- Genetic Determinants of Telomere Length and Their Role in Human Disease: Molecular Mechanisms and Underrepresented Populations' Perspectives.Biomedicines · 2026Review
- Profile of biological aging in first primary cancers: a pan-cancer analysis of two large-scale cohorts from the UK and Hong Kong.BMC medicine · 2025Article
- Clustering of lymphoid neoplasms by cell of origin, somatic mutation and drug usage profiles: a multi-trait genome-wide association study.Blood cancer journal · 2025Article
- A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A Case of Multiple Myeloma in a Patient in Treatment for Chronic Lymphocytic Leukemia.Mediterranean journal of hematology and infectious diseases · 2025Article
- Bayesian-based analysis of the causality between 731 immune cells and erectile dysfunction: a two-sample, bidirectional, and multivariable Mendelian randomization study.Sexual medicine · 2024Article
- Identification and Interpretation of eQTL and eGenes for Hodgkin Lymphoma Susceptibility.Genes · 2023Article
- Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.Leukemia · 2022Article
- Differential Levels of mRNAs in Normal B Lymphocytes, Monoclonal B Lymphocytosis and Chronic Lymphocytic Leukemia Cells from the Same Family Identify Susceptibility Genes.Oncology and therapy · 2021Article
- EOMES is essential for antitumor activity of CD8Leukemia · 2021Article
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- Sequencing at lymphoid neoplasm susceptibility loci maps six myeloma risk genes.Human molecular genetics · 2021Article
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- Genome-Wide Association Analyses Identify Variants inFrontiers in genetics · 2021Article
- Deciphering the Complexity of 3D Chromatin Organization Driving Lymphopoiesis and Lymphoid Malignancies.Frontiers in immunology · 2021Review
- Tracking the Genetic Susceptibility Background of B-Cell Non-Hodgkin's Lymphomas from Genome-Wide Association Studies.International journal of molecular sciences · 2020Review
- Inherited variants at 3q13.33 and 3p24.1 are associated with risk of diffuse large B-cell lymphoma and implicate immune pathways.Human molecular genetics · 2020Article
Corrections and comments
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Authors and funding
41 authors at 17 institutions in 5 countries.
Philip J LawDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Amit SudDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Jonathan S MitchellDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Marc HenrionDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Giulia OrlandoDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Oleg LeniveDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Peter BroderickDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Helen E SpeedyDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
David C JohnsonDivision of Molecular Pathology, The Institute of Cancer Research, London, UK.
Martin KaiserDivision of Molecular Pathology, The Institute of Cancer Research, London, UK.
Niels WeinholdMyeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, USA.
Rosie CookeDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Nicola J SunterNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Graham H JacksonDepartment of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Geoffrey SummerfieldDepartment of Haematology, Queen Elizabeth Hospital, Gateshead, Newcastle upon Tyne, UK.
Robert J HarrisDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
Andrew R PettittDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
David J AllsupQueens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, UK.
Jonathan CarmichaelQueens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, UK.
James R BaileyQueens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, UK.
Guy PrattDepartment of Haematology, Birmingham Heartlands Hospital, Birmingham, UK.
Thahira RahmanNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Chris PepperDepartment of Haematology, School of Medicine, Cardiff University, Cardiff, UK.
Chris FeganCardiff and Vale National Health Service Trust, Heath Park, Cardiff, UK.
Elke Pogge von StrandmannDepartment of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Andreas EngertDepartment of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Asta FörstiDivision of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
Bowang ChenDivision of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
Miguel Inacio da Silva FilhoDivision of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
Hauke ThomsenDivision of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
Per HoffmannInstitute of Human Genetics, University of Bonn, Germany.
Markus M NoethenInstitute of Human Genetics, University of Bonn, Germany.
Lewin EiseleUniversity of Duisburg-Essen, Essen, Germany.
Karl-Heinz JöckelUniversity of Duisburg-Essen, Essen, Germany.
James M AllanNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Hartmut GoldschmidtDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Daniel CatovskyDivision of Molecular Pathology, The Institute of Cancer Research, London, UK.
Gareth J MorganMyeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, USA.
Kari HemminkiDivision of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Institute of Cancer Research · GBGerman Cancer Research Center · DENewcastle University · GBHull and East Yorkshire Hospitals NHS Trust · GBUniversity Hospital Cologne · DEUniversity of Arkansas for Medical Sciences · USUniversity of Duisburg-Essen · DEUniversity of Liverpool · GBCardiff and Vale University Health Board · GBCardiff University · GBCastle Hill Hospital · GBHeartlands Hospital · GBHeidelberg University · DEQueen Elizabeth Hospital · GBRoyal Victoria Infirmary · GBUniversity of Basel · CHUniversity of Bonn · DE
Funding
Cancer Research UK C1298/A8362Medical Research Council G0100132Wellcome TrustWellcome Trust 076113Wellcome Trust 085475
Abstract
B-cell malignancies (BCM) originate from the same cell of origin, but at different maturation stages and have distinct clinical phenotypes. Although genetic risk variants for individual BCMs have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. We explored genome-wide association studies of chronic lymphocytic leukaemia (CLL, N = 1,842), Hodgkin lymphoma (HL, N = 1,465) and multiple myeloma (MM, N = 3,790). We identified a novel pleiotropic risk locus at 3q22.2 (NCK1, rs11715604, P = 1.60 × 10
Indexed as
Genome-Wide Association StudyAdaptor Proteins, Signal TransducingAdultAgedFemaleGenetic PleiotropyGenetic Predisposition to DiseaseHLA-DQ beta-ChainsHLA-DRB1 ChainsHodgkin DiseaseHumansLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedMultiple MyelomaOncogene ProteinsAdaptor Proteins, Signal TransducingHLA-DQB1 antigenHLA-DQ beta-ChainsHLA-DRB1 ChainsNck proteinOncogene Proteins
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