Evidence map›Paper›PMID 28112056›Full record

ArticlePsychological medicine2017

Obstetrical, pregnancy and socio-economic predictors for new-onset severe postpartum psychiatric disorders in primiparous women.

S Meltzer-Brody, M L Maegbaek, S E Medland, W C Miller, P Sullivan, T Munk-Olsen

Open access · greenAbstract read
In one paragraph

Article in Psychological medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 3 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 149 citations in OpenAlex.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 4 countries.

S Meltzer-BrodyDepartment of Psychiatry,University of North Carolina at Chapel Hill,Chapel Hill,NC,USA.
M L MaegbaekNational Center for Register-based Research,Aarhus University,Aarhus,Denmark.
S E MedlandQuantitative Genetics,QIMR Berghofer Medical Research Institute,Brisbane,QLD,Australia.
W C MillerDepartment of Epidemiology,The Ohio State University,Columbus,OH,USA.
P SullivanDepartments of Genetics and Psychiatry,University of North Carolina at Chapel Hill,Chapel Hill,NC,USA.
T Munk-OlsenNational Center for Register-based Research,Aarhus University,Aarhus,Denmark.
Aarhus University · DKKarolinska Institutet · SEQIMR Berghofer Medical Research Institute · AUThe Ohio State University · USUniversity of North Carolina at Chapel Hill · US

Funding

Epidemiological and Genetic Predictors of Postpartum Mood DisordersR01MH104468 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MELTZER-BRODY, SAMANTHA ERIKA · 2014 to 2017
$2.6M
NIMH NIH HHS R01 MH104468
6 · The paper itself

Abstract

backgroundChildbirth is a potent trigger for the onset of psychiatric illness in women including postpartum depression (PPD) and postpartum psychosis (PP). Medical complications occurring during pregnancy and/or childbirth have been linked to postpartum psychiatric illness and sociodemographic factors. We evaluated if pregnancy and obstetrical predictors have similar effects on different types of postpartum psychiatric disorders.

methodA population-based cohort study using Danish registers was conducted in 392 458 primiparous women with a singleton delivery between 1995 and 2012 and no previous psychiatric history. The main outcome was first-onset postpartum psychiatric episodes. Incidence rate ratios (IRRs) were calculated for any psychiatric contact in four quarters for the first year postpartum.

resultsPPD and postpartum acute stress reactions were associated with pregnancy and obstetrical complications. For PPD, hyperemesis gravidarum [IRR 2.69, 95% confidence interval (CI) 1.93-3.73], gestational hypertension (IRR 1.84, 95% CI 1.33-2.55), pre-eclampsia (IRR 1.45, 95% CI 1.14-1.84) and Cesarean section (C-section) (IRR 1.32, 95% CI 1.13-1.53) were associated with increased risk. For postpartum acute stress, hyperemesis gravidarum (IRR 1.93, 95% CI 1.38-2.71), preterm birth (IRR 1.51, 95% CI 1.30-1.75), gestational diabetes (IRR 1.42, 95% CI 1.03-1.97) and C-section (IRR 1.36, 95% CI 1.20-1.55) were associated with increased risk. In contrast, risk of PP was not associated with pregnancy or obstetrical complications.

conclusionsPregnancy and obstetrical complications can increase the risk for PPD and acute stress reactions but not PP. Identification of postpartum women requiring secondary care is needed to develop targeted approaches for screening and treatment. Future work should focus on understanding the contributions of psychological stressors and underlying biology on the development of postpartum psychiatric illness.

Indexed as

AdultDenmarkDepression, PostpartumFemaleHumansObstetric Labor ComplicationsParityPregnancyPsychotic DisordersPuerperal DisordersRegistriesRisk FactorsStress Disorders, Traumatic, AcuteYoung AdultAcute stress disorderobstetrical predictorspostpartum depressionpostpartum psychosispregnancy.

Identifiers

PMID28112056
PMCPMC5429203
OpenAlexW2581977098

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.