ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017
Cerebral collateral therapeutics in acute ischemic stroke: A randomized preclinical trial of four modulation strategies.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06297863 (Head Down Tilt 15° to Increase Collateral Flow in Acute Ischemic Stroke), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Head Down Tilt 15° to Increase Collateral Flow in Acute Ischemic Stroke: a Multicenter, Randomised, Proof of Concept, Phase 2a/b Trial in Patients Treated With Mechanical Thrombectomy
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Head Down Position Before Endovascular Treatment for Large Vessel Occlusion: Clinical Trial Design.Journal of the American Heart Association · 2026Trial
- Head-down position after reperfusion improves cerebral ischaemic injury in rat.Stroke and vascular neurology · 2026Article
- Head Down Tilt 15° to Increase Collateral Flow in Acute Ischemic Stroke: Rationale and Study Protocol of a Multicenter, Randomized, Proof-of-Concept, Phase 2a/b Trial in Patients Treated With Mechanical Thrombectomy (DOWN-SUITE).Stroke (Hoboken, N.J.) · 2026Article
- The similarities and differences among the cerebral perforating arteries, and their clinical implications.Surgical and radiologic anatomy : SRA · 2026Article
- Effect of RICAS (Remote Ischemic Preconditioning on Collaterals of Atherosclerosis Stroke): Rationale and Design.Journal of the American Heart Association · 2025Article
- Perfusion patterns as a tool for emergency stroke diagnosis: differentiating proximal and distal MCA occlusions.BMJ neurology open · 2025Article
- Sanctuary sites in cortical stroke.Frontiers in neurology · 2025Article
- Trendelenburg position for acute anterior circulation ischaemic stroke with large artery atherosclerosis aetiology (HOPES 3): rationale and design.Stroke and vascular neurology · 2024Article
- Head down positioning before recanalization in acute ischemic stroke.European stroke journal · 2024Article
- Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- A Study on the Effects of Different Positions on the Clinical Prognosis of Patients with Acute Ischemic Stroke.Current neurovascular research · 2024Review
- Evaluation of T2-FLAIR combined with ASL on the collateral circulation of acute ischemic stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Collateral Supply in Preclinical Cerebral Stroke Models.Translational stroke research · 2022Review
- Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study.Parkinson's disease · 2022Article
- Effect of head-down tilt on clinical outcome and cerebral perfusion in ischemic stroke patients: A case series.Frontiers in neurology · 2022Article
- Article
- Impact of Acute and Chronic Hypertension on Changes in Pial Collateral Tone In Vivo During Transient Ischemia.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Prostaglandin E1-Mediated Collateral Recruitment Is Delayed in a Neonatal Rat Stroke Model.International journal of molecular sciences · 2018Article
- Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke.Nature reviews. Neurology · 2018Review
- Temporal remodeling of pial collaterals and functional deficits in a murine model of ischemic stroke.Journal of neuroscience methods · 2018Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral collaterals are dynamically recruited after arterial occlusion and highly affect tissue outcome in acute ischemic stroke. We investigated the efficacy and safety of four pathophysiologically distinct strategies for acute modulation of collateral flow (collateral therapeutics) in the rat stroke model of transient middle cerebral artery (MCA) occlusion. A composed randomization design was used to assign rats (n = 118) to receive phenylephrine (induced hypertension), polygeline (intravascular volume load), acetazolamide (cerebral arteriolar vasodilation), head down tilt (HDT) 15° (cerebral blood flow diversion), or no treatment, starting 30 min after MCA occlusion. Compared to untreated animals, treatment with collateral therapeutics was associated with lower infarct volumes (62% relative mean difference; 51.57 mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.