ArticleCurrent opinion in behavioral sciences2017
Adolescence and Drug Use Vulnerability: Findings from Neuroimaging.
Article in Current opinion in behavioral sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 5 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Neuroscience-informed classification of prevention interventions in substance use disorders: An RDoC-based approach.Neuroscience and biobehavioral reviews · 2024Pooled it
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Adverse childhood experiences and substance misuse in young people in India: results from the multisite cVEDA cohort.BMC public health · 2021Pooled it
- Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration.Clinical psychology review · 2021Pooled it
- Neurobiological and Cognitive Profile of Young Binge Drinkers: a Systematic Review and Meta-Analysis.Neuropsychology review · 2019Pooled it
- The impact of an educational program based on self-regulation theory on reducing alcohol consumption among adolescents: a randomized controlled trial.BMC public health · 2025Trial
- Narrative Review of Novel Nicotine-Delivery Systems and Emerging Pharmaceuticals for Tobacco Cessation.Medicines (Basel, Switzerland) · 2026Review
- Risk for Adolescent Substance Use Initiation: Associations with Large-Scale Brain Network Recruitment During Emotional Inhibitory Control.Behavioral sciences (Basel, Switzerland) · 2025Article
- Co-design of digital public health substance use resources: A collaboration between young people and experts.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2025Article
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
- Efficacy of a neuroscience informed psychoeducation intervention on cognitive, emotional, and substance use outcomes in college students: a pilot study.Frontiers in psychiatry · 2025Article
- Neuroscience-informed psychoeducation for addiction: a conceptual and feasibility study.Frontiers in psychiatry · 2025Article
- Enhancing causal inference in population-based neuroimaging data in children and adolescents.Developmental cognitive neuroscience · 2024Review
- Neuroimaging Biomarkers in Addiction.medRxiv : the preprint server for health sciences · 2024Article
- Characterization of the Neurochemical and Behavioral Effects of the Phenethylamine 2-Cl-4,5-MDMA in Adolescent and Adult Male Rats.The international journal of neuropsychopharmacology · 2024Article
- Predictors of Substance Use Initiation by Early Adolescence.The American journal of psychiatry · 2024Article
- Associations Between Family History of Alcohol and/or Substance Use Problems and Frontal Cortical Development From 9 to 13 Years of Age: A Longitudinal Analysis of the ABCD Study.Biological psychiatry global open science · 2024Article
- Differences in Brain Network Topology Based on Alcohol Use History in Adolescents.Brain sciences · 2023Article
- Concordance between substance use self-report and hair analysis in community-based adolescents.The American journal of drug and alcohol abuse · 2023Article
- Characterizing heterogeneity in early adolescent reward networks and individualized associations with behavioral and clinical outcomes.Network neuroscience (Cambridge, Mass.) · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Adolescence is a period of vulnerability for developing substance use disorder. Recent neuropsychological and neuroimaging studies have elucidated underlying neural vulnerabilities that contribute to initiation of substance use during adolescence. Findings suggest poorer performance on tasks of inhibition and working memory, smaller brain volumes in reward and cognitive control regions, less brain activation during executive functioning tasks, and heightened reward responsivity are predictive of youth initiating substance use during adolescence. In youth who are family history positive (FHP) for substance use disorder, poorer executive functioning, smaller volume of limbic brain regions (e.g., amygdala), sex-specific patterns of hippocampal volume, and a positive association between nucleus accumbens volume and family history density have been reported. Further, reduced white matter integrity, altered brain response during inhibitory control, including both greater and less frontal lobe response, blunted emotional processing, and weaker neural connectivity have also been found in FHP youth. Thus, there is significant overlap among the neural precursors shown to be predictive of alcohol and substance use initiation during adolescence and those that distinguish FHP from youth without a family history of substance use disorder, suggesting common targets for prevention and intervention. Understanding these predictive factors helps identify at-risk youth for prevention efforts, as well as create interventions targeting cognitive weaknesses or brain regions involved in substance use initiation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.