ArticleFrontiers in aging neuroscience2016
The Functional Integration in the Sensory-Motor System Predicts Aging in Healthy Older Adults.
Article in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06891014 (Effects of Regular Exercise on Sensory-motor Functions and Fall Risk in the Elderly), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Regular Exercise on Sensory-motor Functions and Fall Risk in the Elderly
Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Effects of vibrotactile-enhanced music-based intervention on sensorimotor control capacity in the hand of an aging brain: a pilot feasibility randomized crossover trial.BMC geriatrics · 2021Trial
- Better Together: Technology-Use Gaps and Loneliness in Older Adults.Behavioral sciences (Basel, Switzerland) · 2026Article
- Targeting neuroplasticity in old brain: restoring synapse with cognitive strategies.Biogerontology · 2026Review
- Aging impairs bimanual isometric force smoothness.EXCLI journal · 2026Article
- Relationships of functional connectivity of motor cortex, primary somatosensory cortex, and cerebellum to balance performance in middle-aged and older adults.Neurobiology of aging · 2025Article
- The effect of advanced age and stool modification on reaching distance in sitting.Journal of physical therapy science · 2024Article
- Development of the Sensory-Motor Dysfunction Questionnaire and Pilot Reliability Testing.Brain sciences · 2024Article
- Stimulated cervical afferent input increases postural instability in older people with chronic neck pain: a cross-sectional study.BMC geriatrics · 2024Article
- Brain-wide functional connectome analysis of 40,000 individuals reveals brain networks that show aging effects in older adults.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Age-related GABAergic differences in the primary sensorimotor cortex: A multimodal approach combining PET, MRS and TMS.NeuroImage · 2021Article
- The Association between Age-Related Changes in Oral Neuromechanics and Alzheimer's Disease.Advances in geriatric medicine and research · 2021Article
- Brain Network Segregation and Glucose Energy Utilization: Relevance for Age-Related Differences in Cognitive Function.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Resting state connectivity within the basal ganglia and gait speed in older adults with cerebral small vessel disease and locomotor risk factors.NeuroImage. Clinical · 2020Article
- Impaired motor skills and atypical functional connectivity of the sensorimotor system in 40- to 65-year-old adults with autism spectrum disorders.Neurobiology of aging · 2020Article
- Age-Related Changes in Pain Perception Are Associated With Altered Functional Connectivity During Resting State.Frontiers in aging neuroscience · 2020Article
- Decreased inter-hemispheric interactions but increased intra-hemispheric integration during typical aging.Aging · 2019Article
- Detecting the Information of Functional Connectivity Networks in Normal Aging Using Deep Learning From a Big Data Perspective.Frontiers in neuroscience · 2019Article
- Hub Patterns-Based Detection of Dynamic Functional Network Metastates in Resting State: A Test-Retest Analysis.Frontiers in neuroscience · 2019Article
- Loss of functional connectivity is an early imaging marker in primary lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2018Article
- Effects of lorazepam and baclofen on short- and long-latency afferent inhibition.The Journal of physiology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Healthy aging is typically accompanied by a decrease in the motor capacity. Although the disrupted neural representations and performance of movement have been observed in older age in previous studies, the relationship between the functional integration of sensory-motor (SM) system and aging could be further investigated. In this study, we examine the impact of healthy aging on the resting-state functional connectivity (rsFC) of the SM system, and investigate as to how aging is affecting the rsFC in SM network. The SM network was identified and evaluated in 52 healthy older adults and 51 younger adults using two common data analytic approaches: independent component analysis and seed-based functional connectivity (seed at bilateral M1 and S1). We then evaluated whether the altered rsFC of the SM network could delineate trajectories of the age of older adults using a machine learning methodology. Compared with the younger adults, the older demonstrated reduced functional integration with increasing age in the mid-posterior insula of SM network and increased rsFC among the sensorimotor cortex. Moreover, the reduction in the rsFC of mid-posterior insula is associated with the age of older adults. Critically, the analysis based on two-aspect connectivity-based prediction frameworks revealed that the age of older adults could be reliably predicted by this reduced rsFC. These findings further indicated that healthy aging has a marked influence on the SM system that would be associated with a reorganization of SM system with aging. Our findings provide further insight into changes in sensorimotor function in the aging brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.