Evidence map›Paper›PMID 28111539›Full record

ArticleFrontiers in neuroscience2016

Dynamic Expression of Serotonin Receptor 5-HT3A in Developing Sensory Innervation of the Lower Urinary Tract.

K Elaine Ritter, E Michelle Southard-Smith

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Innervation in organogenesis.Current topics in developmental biology · 2022
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

K Elaine RitterDivision of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine Nashville, TN, USA.
E Michelle Southard-SmithDivision of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine Nashville, TN, USA.
Vanderbilt University · US

Funding

Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Neural Crest Contributions to the Lower Urinary TractR01DK078158 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SOUTHARD-SMITH, E MICHELLE · 2007 to 2017
$2.1M
Gene Networks in Neural Crest-derived Innervation of the Lower Urinary TractRC1DK086594 · NIDDK · VANDERBILT UNIVERSITY · PI SOUTHARD-SMITH, E MICHELLE · 2009 to 2010
$738k
Mapping serotonin receptors in lower urinary tract innervationU01DK101038 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SOUTHARD-SMITH, E MICHELLE · 2013 to 2013
$295k
Neural Crest Contributions to the Lower Urinary TractR56DK078158 · NIDDK · VANDERBILT UNIVERSITY · PI SOUTHARD-SMITH, E MICHELLE · 2012 to 2012
$150k
Roles for Serotonin in Autonomic Innervation of the Lower Urinary TractF31DK097938 · NIDDK · VANDERBILT UNIVERSITY · PI RITTER, KAREN ELAINE · 2013 to 2016
$110k
NICHD NIH HHS U54 HD083211NIDDK NIH HHS F31 DK097938NIDDK NIH HHS R01 DK078158NIDDK NIH HHS R56 DK078158NIDDK NIH HHS RC1 DK086594NIDDK NIH HHS U01 DK101038
6 · The paper itself

Abstract

Sensory afferent signaling is required for normal function of the lower urinary tract (LUT). Despite the wide prevalence of bladder dysfunction and pelvic pain syndromes, few effective treatment options are available. Serotonin receptor 5-HT3A is a known mediator of visceral afferent signaling and has been implicated in bladder function. However, basic expression patterns for this gene and others among developing bladder sensory afferents that could be used to inform regenerative efforts aimed at treating deficiencies in pelvic innervation are lacking. To gain greater insight into the molecular characteristics of bladder sensory innervation, we conducted a thorough characterization of

Indexed as

autonomic nervous systemdorsal root ganglialower urinary tractneural crestserotonin

Identifiers

PMID28111539
PMCPMC5216032
OpenAlexW2570673926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.