Observational studyJournal of the American Heart Association2017
Diffuse Myocardial Fibrosis Reduces Electrocardiographic Voltage Measures of Left Ventricular Hypertrophy Independent of Left Ventricular Mass.
Observational study in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Within a Heartbeat: A Machine Learning Approach Using VCG for Heart Failure Assessment in Sinus Rhythm.Journal of personalized medicine · 2026Article
- Integrating ECG Into the Mayo Score Enhances Genotype Prediction in Hypertrophic Cardiomyopathy.Journal of the American Heart Association · 2026Article
- Longevity mechanisms in cardiac aging: exploring calcium dysregulation and senescence.Biogerontology · 2025Review
- Importance of T1-Mapping Sequence in Patients with Hypertrophic Cardiomyopathy without Foci of Non-Ischemic Myocardial Injury in Late Gadolinium Enhancement Sequence.Biomedicines · 2024Article
- Accurate diagnosis of apical hypertrophic cardiomyopathy using explainable advanced electrocardiogram analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Estimating Left Ventricular Mass from the Electrocardiogram across the Spectrum of LV Mass from Normal to Increased LV Mass in an Older Age Group.Cardiology research and practice · 2024Article
- Electrocardiographic Markers of Adverse Left Ventricular Remodeling and Myocardial Fibrosis in Severe Aortic Stenosis.Journal of clinical medicine · 2023Article
- Comparison of electrocardiographic versus echocardiographic detection of left ventricular mass changes over time and evaluation of new onset left ventricular hypertrophy.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Low QRS Voltages in Cardiac Amyloidosis: Clinical Correlates and Prognostic Value.JACC. CardioOncology · 2022Article
- Improved evaluation of left ventricular hypertrophy using the spatial QRS-T angle by electrocardiography.Scientific reports · 2022Observational
- Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis.Science advances · 2022Article
- Electrocardiographic parameters of left ventricular hypertrophy and prediction of mortality in hemodialysis patients.Journal of nephrology · 2022Article
- Discrepancy between left ventricular hypertrophy by echocardiography and electrocardiographic hypertrophy: clinical characteristics and outcomes.Open heart · 2021Article
- Left Ventricular Extracellular Volume Expansion Is Not Associated with Atrial Fibrillation or Atrial Fibrillation-mediated Left Ventricular Systolic Dysfunction.Radiology. Cardiothoracic imaging · 2020Article
- The transition from hypertension to hypertensive heart disease and heart failure: the PREFERS Hypertension study.ESC heart failure · 2020Article
- Article
- IFITM3 protects the heart during influenza virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cornell product in an electrocardiogram is related to reduced LV regional wall motion.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Electrocardiographic criteria for cardiac remodeling in hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- The Evolving Role of Cardiovascular Magnetic Resonance Imaging in the Evaluation of Systemic Amyloidosis.Magnetic resonance insights · 2019Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundMyocardial fibrosis quantified by myocardial extracellular volume fraction (ECV) and left ventricular mass (LVM) index (LVMI) measured by cardiovascular magnetic resonance might represent independent and opposing contributors to ECG voltage measures of left ventricular hypertrophy (LVH). Diffuse myocardial fibrosis can occur in LVH and interfere with ECG voltage measures. This phenomenon could explain the decreased sensitivity of LVH detectable by ECG, a fundamental diagnostic tool in cardiology. METHODS AND
resultsWe identified 77 patients (median age, 53 [interquartile range, 26-60] years; 49% female) referred for contrast-enhanced cardiovascular magnetic resonance with ECV measures and 12-lead ECG. Exclusion criteria included clinical confounders that might influence ECG measures of LVH. We evaluated ECG voltage-based LVH measures, including Sokolow-Lyon index, Cornell voltage, 12-lead voltage, and the vectorcardiogram spatial QRS voltage, with respect to LVMI and ECV. ECV and LVMI were not correlated (R
conclusionsMyocardial mass and diffuse myocardial fibrosis have independent and opposing effects upon ECG voltage measures of LVH. Diffuse myocardial fibrosis quantified by ECV can obscure the ECG manifestations of increased LVM. This provides mechanistic insight, which can explain the limited sensitivity of the ECG for detecting increased LVM.
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