ArticleCell host & microbe2017
Systematic Characterization and Analysis of the Taxonomic Drivers of Functional Shifts in the Human Microbiome.
Article in Cell host & microbe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Integrative metagenomic analysis reveals distinct gut microbial signatures related to obesity.BMC microbiology · 2024Pooled it
- Pooled it
- Trial
- From gut dysbiosis to eubiosis: understanding microbiome recovery as an ecological process.Gut microbes · 2026Review
- MAAMOUL: metabolic network-based discovery of microbiome-metabolome shifts in disease.Bioinformatics (Oxford, England) · 2026Article
- Normative assembly rule reveals fairness in microbial communities.PLoS biology · 2026Article
- MAAMOUL: Metabolic network-based discovery of microbiome-metabolome shifts in disease.bioRxiv : the preprint server for biology · 2026Article
- Cross-cohort meta-analysis reveals conserved gut microbiome signatures of insomnia.Current research in microbial sciences · 2026Article
- Data-driven enterosignatures link gut microbiome reorganization to heat stress responses in lactating sows.Frontiers in microbiology · 2026Article
- Sequence modeling tools to decode the biosynthetic diversity of the human microbiome.mSystems · 2025Review
- Microbiome-metabolome dynamics associated with impaired glucose control and responses to lifestyle changes.Nature medicine · 2025Article
- Profiling the composition of resistome and bacteriome in the upper respiratory tract of domestic cats with respiratory signs in China.Microbiome research reports · 2025Article
- Global compositional and functional states of the human gut microbiome in health and disease.Genome research · 2024Article
- Coumarin derivatives ameliorate the intestinal inflammation and pathogenic gut microbiome changes in the model of infectious colitis through antibacterial activity.Frontiers in cellular and infection microbiology · 2024Article
- High-resolution characterization of short-term temporal variability in the taxonomic and resistome composition of wastewater influent.Microbial genomics · 2023Article
- Multi-omics profiles of the intestinal microbiome in irritable bowel syndrome and its bowel habit subtypes.Microbiome · 2023Article
- Oral administration ofFrontiers in veterinary science · 2023Article
- Efficient computation of contributional diversity metrics from microbiome data with FuncDiv.Bioinformatics (Oxford, England) · 2023Article
- The microbiome's fiber degradation profile and its relationship with the host diet.BMC biology · 2022Article
- Integrating phylogenetic and functional data in microbiome studies.Bioinformatics (Oxford, England) · 2022Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Comparative analyses of the human microbiome have identified both taxonomic and functional shifts that are associated with numerous diseases. To date, however, microbiome taxonomy and function have mostly been studied independently and the taxonomic drivers of functional imbalances have not been systematically identified. Here, we present FishTaco, an analytical and computational framework that integrates taxonomic and functional comparative analyses to accurately quantify taxon-level contributions to disease-associated functional shifts. Applying FishTaco to several large-scale metagenomic cohorts, we show that shifts in the microbiome's functional capacity can be traced back to specific taxa. Furthermore, the set of taxa driving functional shifts and their contribution levels vary markedly between functions. We additionally find that similar functional imbalances in different diseases are driven by both disease-specific and shared taxa. Such integrated analysis of microbiome ecological and functional dynamics can inform future microbiome-based therapy, pinpointing putative intervention targets for manipulating the microbiome's functional capacity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.