ArticleHuman immunology2017
High resolution HLA haplotyping by imputation for a British population bioresource.
Article in Human immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Viral diversity influences T-cell responses to enteric human adenoviruses F40 and F41.Virus evolution · 2026Article
- HLA Genetics for the Human Diseases.Advances in experimental medicine and biology · 2024Review
- Regulation of expression quantitative trait loci by SVA retrotransposons within the major histocompatibility complex.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Human leukocyte antigen super-locus: nexus of genomic supergenes, SNPs, indels, transcripts, and haplotypes.Human genome variation · 2022Review
- On the peptide binding affinity changes in population-specific HLA repertoires to the SARS-CoV-2 variants Delta and Omicron.Journal of autoimmunity · 2022Article
- HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease.Clinical and translational science · 2022Article
- Improving Access to HLA-Matched Kidney Transplants for African American Patients.Frontiers in immunology · 2022Article
- No strong HLA association with MOG antibody disease in the UK population.Annals of clinical and translational neurology · 2021Article
- Identification of Novel Candidate CD8Viruses · 2021Article
- An immunogenetic view of COVID-19.Genetics and molecular biology · 2021Article
- Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leucocyte antigen locus.Genes and immunity · 2020Article
- A Novel Framework for Characterizing Genomic Haplotype Diversity in the Human Immunoglobulin Heavy Chain Locus.Frontiers in immunology · 2020Article
- Low Hydrophobic Mismatch Scores Calculated for HLA-A/B/DR/DQ Loci Improve Kidney Allograft Survival.Frontiers in immunology · 2020Article
- Transgenic T-cell receptor immunotherapy for cancer: building on clinical success.Therapeutic advances in vaccines and immunotherapy · 2020Review
- Fasting hepatic de novo lipogenesis is not reliably assessed using circulating fatty acid markers.The American journal of clinical nutrition · 2019Article
- Distinct HLA associations of LGI1 and CASPR2-antibody diseases.Brain : a journal of neurology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
This study aimed to establish the occurrence and frequency of HLA alleles and haplotypes for a healthy British Caucasian population bioresource from Oxfordshire. We present the results of imputation from HLA SNP genotyping data using SNP2HLA for 5553 individuals from Oxford Biobank, defining one- and two-field alleles together with amino acid polymorphisms. We show that this achieves a high level of accuracy with validation using sequence-specific primer amplification PCR. We define six- and eight-locus HLA haplotypes for this population by Bayesian methods implemented using PHASE. We determine patterns of linkage disequilibrium and recombination for these individuals involving classical HLA loci and show how analysis within a haplotype block structure may be more tractable for imputed data. Our findings contribute to knowledge of HLA diversity in healthy populations and further validate future large-scale use of HLA imputation as an informative approach in population bioresources.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.