ArticleCurrent biology : CB2017
Control of Movement Initiation Underlies the Development of Balance.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 100 citations in OpenAlex.
- Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish.Proceedings. Biological sciences · 2026Article
- Directionally biased neuronal responses to pitch-axis vestibular stimulation in larval zebrafish compared to roll-axis responses.Communications biology · 2026Article
- Vertical optokinetic eye movements in the larval zebrafish.The Journal of experimental biology · 2026Article
- Head stabilization behavior and underlying circuit mechanisms in larval zebrafish.Communications biology · 2026Article
- Distinct developmental dynamics of opposing persistent currents shape motoneuron firing during motor maturation of zebrafish.The Journal of physiology · 2026Article
- Whole-body central processing of lateral line inputs encodes flow direction relative to the center-of-mass.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae.Communications biology · 2026Article
- Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Oligodendrocytes support functional development of subcortical premotor neurons and navigation.bioRxiv : the preprint server for biology · 2025Article
- High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae.bioRxiv : the preprint server for biology · 2025Article
- Article
- Larval zebrafish maintain elevation with multisensory control of posture and locomotion.The Journal of experimental biology · 2025Article
- Larval zebrafish maintain elevation with multisensory control of posture and locomotion.bioRxiv : the preprint server for biology · 2025Article
- Article
- Protective Effects of Fasudil Against Cisplatin-Induced Ototoxicity in Zebrafish: An In Vivo Study.International journal of molecular sciences · 2024Article
- Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (bioRxiv : the preprint server for biology · 2024Article
- Evolutionarily conserved brainstem architecture enables gravity-guided vertical navigation.PLoS biology · 2024Article
- The Vestibulospinal Nucleus Is a Locus of Balance Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Genomic and single-cell analyses reveal genetic signatures of swimming pattern and diapause strategy in jellyfish.Nature communications · 2024Article
- Measuring Optokinetic Reflex and Vestibulo-Ocular Reflex in Unilateral Vestibular Organ Damage Model of Zebrafish.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Balance arises from the interplay of external forces acting on the body and internally generated movements. Many animal bodies are inherently unstable, necessitating corrective locomotion to maintain stability. Understanding how developing animals come to balance remains a challenge. Here we study the interplay among environment, sensation, and action as balance develops in larval zebrafish. We first model the physical forces that challenge underwater balance and experimentally confirm that larvae are subject to constant destabilization. Larvae propel in swim bouts that, we find, tend to stabilize the body. We confirm the relationship between locomotion and balance by changing larval body composition, exacerbating instability and eliciting more frequent swimming. Intriguingly, developing zebrafish come to control the initiation of locomotion, swimming preferentially when unstable, thus restoring preferred postures. To test the sufficiency of locomotor-driven stabilization and the developing control of movement timing, we incorporate both into a generative model of swimming. Simulated larvae recapitulate observed postures and movement timing across early development, but only when locomotor-driven stabilization and control of movement initiation are both utilized. We conclude the ability to move when unstable is the key developmental improvement to balance in larval zebrafish. Our work informs how emerging sensorimotor ability comes to impact how and why animals move when they do.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.