ArticleCurrent biology : CB2017
Increases in Physical Activity Result in Diminishing Increments in Daily Energy Expenditure in Mice.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Hepatic ketogenic insufficiency blunts exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.Function (Oxford, England) · 2026Article
- Non-invasive ovulation tracking enables genetic engineering in wild rodents.Cell reports methods · 2026Article
- Disulfiram Protects Against Diet-Induced Obesity by Reprogramming Systemic Lipid Partitioning Independent of GSDMD.bioRxiv : the preprint server for biology · 2026Article
- Improvements in body composition, functional capacity, and cardiovascular fitness: results of a workplace wellness program in the United Arab Emirates.Frontiers in sports and active living · 2026Article
- Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy.The Journal of physiology · 2026Article
- The impact of housing and high-fructose diet on behavior and cardiovascular response to eucalyptus wildfire smoke in WKY rats.Journal of toxicology and environmental health. Part A · 2026Article
- Obesity drives temporally distinct physical activity disruptions in mice under a fixed 24-h light-dark cycle.Scientific reports · 2025Article
- Voluntary Exercise-Induced Skeletal Muscle Responses in Young and Aged Mice on a High-Fat Diet.Cureus · 2025Article
- Gradual increase in energy intake over 8 weeks with voluntary wheel running limits body weight change in male rats.The British journal of nutrition · 2025Article
- Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport.Cell metabolism · 2024Article
- Use of a Fitbit-like device in rats: Sex differences, relation to EEG sleep, and use to measure the long-term effects of adolescent ethanol exposure.Alcohol, clinical & experimental research · 2023Article
- Impact of energy availability and physical activity on variation in fertility across human populations.Journal of physiological anthropology · 2023Review
- Neurotensin neurons in the extended amygdala control dietary choice and energy homeostasis.Nature neuroscience · 2022Article
- Insulin blood-brain barrier transport and interactions are greater following exercise in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Exercise in People With Cancer: A Spotlight on Energy Regulation and Cachexia.Frontiers in physiology · 2022Review
- Evaluation of secondary electronic cigarette inhalation on lipid metabolism in C57BL/6J mice using indirect calorimetry.Metabolism open · 2021Article
- Article
- Effects of acute exercise on spontaneous physical activity in mice at different ages.BMC sports science, medicine & rehabilitation · 2021Article
- Energy Status Differentially Modifies Feeding Behavior and POMCFrontiers in endocrinology · 2021Article
- Voluntary Exercise Suppresses Choroidal Neovascularization in Mice.Investigative ophthalmology & visual science · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Exercise is a common component of weight loss strategies, yet exercise programs are associated with surprisingly small changes in body weight [1-4]. This may be due in part to compensatory adaptations, in which calories expended during exercise are counteracted by decreases in other aspects of energy expenditure [1, 5-10]. Here we examined the relationship between a rodent model of voluntary exercise- wheel running- and total daily energy expenditure. Use of a running wheel for 3 to 7 days increased daily energy expenditure, resulting in a caloric deficit of ∼1 kcal/day; however, total daily energy expenditure remained stable after the first week of wheel access, despite further increases in wheel use. We hypothesized that compensatory mechanisms accounted for the lack of increase in daily energy expenditure after the first week. Supporting this idea, we observed a decrease in off-wheel ambulation when mice were using the wheels, indicating behavioral compensation. Finally, we asked whether individual variation in wheel use within a group of mice would be associated with different levels of daily energy expenditure. Despite a large variation in wheel running, we did not observe a significant relationship between the amount of daily wheel running and total daily energy expenditure or energy intake across mice. Together, our experiments support a model in which the transition from sedentary to light activity is associated with an increase in daily energy expenditure, but further increases in physical activity produce diminishingly small increments in daily energy expenditure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.