ArticleMechanisms of ageing and development2017
Obesity induces pro-inflammatory B cells and impairs B cell function in old mice.
Article in Mechanisms of ageing and development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 77 citations in OpenAlex.
- Low-dose tamoxifen ameliorates ovariectomy-induced metabolic and immune dysfunction.GeroScience · 2026Article
- Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review).Molecular medicine reports · 2026Review
- Gut microbiota-derived metabolites as immune modulators in aging and age-related chronic inflammatory diseases.Ageing research reviews · 2026Review
- Aging impairs peroxisome biogenesis in human B cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Immunoglobulin G in aging and cancer.Frontiers in immunology · 2026Review
- Body condition, age, and sex as modulators of peripheral blood immune-cell populations and lymphocyte proliferation in cats.Frontiers in veterinary science · 2026Article
- Adipose immune microenvironment: catalyst of age-related adipose tissue dysfunction.Immunity & ageing : I & A · 2025Review
- Association between novel inflammatory biomarkers SII, SIRI, and obesity in sedentary adults: NHANES 2007-2020.Scientific reports · 2025Article
- Obesity accelerates cardiovascular ageing.European heart journal · 2025Review
- T-bet-expressing B cells promote atherosclerosis in apolipoprotein E-deficient mice.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Exploring How Adipose Tissue, Obesity, and Gender Influence the Immune Response to Vaccines: A Comprehensive Narrative Review.International journal of molecular sciences · 2025Review
- Article
- Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis.Cell reports · 2024Article
- Emerging insights into atypical B cells in pediatric chronic infectious diseases and immune system disorders: T(o)-bet on control of B-cell immune activation.The Journal of allergy and clinical immunology · 2024Review
- From the Sun to the Cell: Examining Obesity through the Lens of Vitamin D and Inflammation.Metabolites · 2023Review
- Associations of metabolic heterogeneity of obesity with frailty progression: Results from two prospective cohorts.Journal of cachexia, sarcopenia and muscle · 2023Article
- Immunometabolism in type 2 diabetes mellitus: tissue-specific interactions.Archives of medical science : AMS · 2023Article
- Phenotypic and functional features of B cells from two different human subcutaneous adipose depots.PloS one · 2023Article
- Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses.Immunity & ageing : I & A · 2022Article
- The Role of B Lymphocyte Subsets in Adipose Tissue Development, Metabolism, and Aging.Comprehensive Physiology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We analyzed B cells infiltrating the Visceral Adipose Tissue (VAT) of young and old mice to identify contributors to the phenotypic and functional changes observed in aged B cells. We found higher percentages of pro-inflammatory (age-associated B cells, ABC) and less Follicular (FO) B cells in VAT as compared to spleen. VAT B cells express higher pro-adipogenic and inflammatory markers, including NF-kB, as compared to splenic B cells, and also secrete IgG2c antibodies, some of which have been shown to be autoimmune in other studies. Moreover, we found that in the presence of an adipocyte-conditioned medium FO B cells differentiated into ABC. Additional results showed production of pro-inflammatory chemokines by the adipocytes, suggesting a mechanism for B cell attraction by the VAT. These results are the first to show a direct effect of adipocytes on the generation of pro-inflammatory B cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.