ArticleReproductive toxicology (Elmsford, N.Y.)2017
Effects of perfluorinated chemicals on thyroid function, markers of ovarian reserve, and natural fertility.
Article in Reproductive toxicology (Elmsford, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Thyroid function tests and serum anti-Müllerian hormone in various populations, is there any association? A systematic review and meta-analysis.Archives of gynecology and obstetrics · 2025Pooled it
- Assessment of ovarian dysfunction induced by environmental toxins: a systematic review.Frontiers in public health · 2025Pooled it
- Environmental Exposure to Per- and Polyfluorylalkyl Substances (PFASs) and Reproductive Outcomes in the General Population: A Systematic Review of Epidemiological Studies.International journal of environmental research and public health · 2024Pooled it
- Persistent organic pollutants and couple fecundability: a systematic review.Human reproduction update · 2021Pooled it
- Association between perfluoroalkyl substances exposure and thyroid function in adults: A meta-analysis.PloS one · 2018Pooled it
- Adsorption and detoxification of poly- and perfluoroalkyl substances (PFAS) with hydrophobic bentonite clays.Environmental science and pollution research international · 2026Article
- In vivo gamete toxicology in the context of in vitro fertilization: a narrative review.F&S reviews · 2025Article
- Breaking the Perfluorooctane Sulfonate Chain: Piezocatalytic Decomposition of PFOS Using BaTiOSmall science · 2024Article
- Review
- Per- and Polyfluoroalkyl Substances and Anti-Müllerian Hormone Concentrations in Two Preconception Cohort Studies.Environmental health perspectives · 2023Article
- Relationship between the Consumption of Fermented Red Beetroot Juice and Levels of Perfluoroalkyl Substances in the Human Body's Fluids and Blood Parameters.International journal of molecular sciences · 2023Article
- Electrochemical degradation of per- and poly-fluoroalkyl substances in the presence of natural organic matter.Separation and purification technology · 2023Article
- Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease.Toxicology · 2022Review
- Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels.International journal of molecular sciences · 2021Review
- Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility?International journal of environmental research and public health · 2021Review
- Endocrine Disruptor Potential of Short- and Long-Chain Perfluoroalkyl Substances (PFASs)-A Synthesis of Current Knowledge with Proposal of Molecular Mechanism.International journal of molecular sciences · 2021Review
- Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models.Advances in pharmacology (San Diego, Calif.) · 2021Article
- Effects of Environmental EDCs on Oocyte Quality, Embryo Development, and the Outcome in Human IVF Process.Advances in experimental medicine and biology · 2021Article
- Risk to human health related to the presence of perfluoroalkyl substances in food.EFSA journal. European Food Safety Authority · 2020Article
- Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina.Environmental health perspectives · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Perfluorinated chemicals (PFCs) can act as endocrine-disrupting chemicals, but there has been limited study of their effects on ovarian reserve or fecundability. 99 women, 30-44 years old, without infertility were followed until pregnancy. Initially, serum was evaluated for Antimullerian hormone (AMH), thyroid hormones: thyroid stimulating hormone (TSH), thyroxine (T4), free thyroxine (fT4), and triiodothyronine (T3), and PFCs: perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS). Bivariate analyses assessed the relationship between thyroid hormones, AMH, and PFCs. Fecundability ratios (FR) were determined for each PFC using a discrete time-varying Cox model and a day-specific probability model. PFC levels were positively correlated with each other (r 0.24-0.90), but there was no correlation with TSH (r 0.02-0.15) or AMH (r -0.01 to -0.15). FR point estimates for each PFC were neither strong nor statistically significant. Although increased exposure to PFCs correlates with thyroid hormone levels, there is no significant association with fecundability or ovarian reserve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.