Evidence map›Paper›PMID 28111017›Full record

ArticleStructure (London, England : 1993)2017

Structural Mimicry by a Bacterial F Box Effector Hijacks the Host Ubiquitin-Proteasome System.

Kathy Wong, John D Perpich, Guennadi Kozlov, Miroslaw Cygler, Yousef Abu Kwaik, Kalle Gehring

Open access · bronzeAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. New microbes and new infections · 2025
    Review
  6. Infection and immunity · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Eat or Be Eaten: Strategies Used byInfection and immunity · 2023
    Review
  11. Article
  12. Molecular Mechanisms UnderlyingFrontiers in immunology · 2022
    Article
  13. mBio · 2021
    Article
  14. Evolution and Adaptation ofBiomolecules · 2021
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Host FIH-Mediated Asparaginyl Hydroxylation of TranslocatedFrontiers in cellular and infection microbiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Kathy WongDepartment of Biochemistry and Groupe de recherche axé sur la structure des protéines, McGill University, Montreal, QC H3G 0B1, Canada.
John D PerpichDepartment of Microbiology and Immunology, University of Louisville College of Medicine, Louisville, KY 40202, USA.
Guennadi KozlovDepartment of Biochemistry and Groupe de recherche axé sur la structure des protéines, McGill University, Montreal, QC H3G 0B1, Canada.
Miroslaw CyglerDepartment of Biochemistry, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Yousef Abu KwaikDepartment of Microbiology and Immunology, University of Louisville College of Medicine, Louisville, KY 40202, USA.
Kalle GehringDepartment of Biochemistry and Groupe de recherche axé sur la structure des protéines, McGill University, Montreal, QC H3G 0B1, Canada. Electronic address: kalle.gehring@mcgill.ca.
McGill University · CAUniversity of Louisville · USUniversity of Saskatchewan · CA

Funding

ZINC FINGER-DNA COMPLEXP41RR001646 · NCRR · CORNELL UNIVERSITY ITHACA · PI CINGOLANI, GINO · 1985 to 2011
$23.8M
Molecular and Cellular Pathogenesis of LegionellaR01AI120244 · NIAID · UNIVERSITY OF LOUISVILLE · PI ABU KWAIK, YOUSEF A · 2015 to 2019
$1.9M
Exploitation of host glycolysis by LegionellaR21AI116517 · NIAID · UNIVERSITY OF LOUISVILLE · PI ABU KWAIK, YOUSEF A · 2015 to 2016
$413k
CIHR GSP-48370NCRR NIH HHS P41 RR001646NIAID NIH HHS R01 AI120244NIAID NIH HHS R21 AI116517NIGMS NIH HHS DMR-0225180
6 · The paper itself

Abstract

Ankyrin B (AnkB/LegAU13) is a translocated F box effector essential for the intracellular replication of the pathogen Legionella pneumophila. AnkB co-opts a host ubiquitin ligase to decorate the pathogen-containing vacuole with K

Indexed as

Host-Pathogen InteractionsAmino Acid SequenceAnkyrinsBinding SitesCell LineCloning, MolecularCrystallography, X-RayEscherichia coliGene ExpressionHumansKineticsLegionella pneumophilaMacrophagesModels, MolecularMolecular MimicryPeriplasmic ProteinsAnkyrinsPeriplasmic ProteinsProteasome Endopeptidase ComplexRecombinant ProteinsSKP1 protein, humanS-Phase Kinase-Associated ProteinsUbiquitinankyrin repeatsbacterial effectorsE3 ubiquitin ligaseF box proteinlegionnaires' diseaselpg2144X-ray crystallography

Identifiers

PMID28111017
PMCPMC6528793
OpenAlexW2572827199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.