Evidence map›Paper›PMID 28110638›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2017

Assessing exercise cardiac reserve using real-time cardiovascular magnetic resonance.

Thu-Thao Le, Jennifer Ann Bryant, Alicia Er Ting, Pei Yi Ho, Boyang Su, Raymond Choon Chye Teo, Julian Siong-Jin Gan, Yiu-Cho Chung, Declan P O'Regan, Stuart A Cook and 1 more

Registry-linked trialAbstract readVideo-Audio Media
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03040947 (MRI Sequence and Imaging Protocol Development), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03040947 unknown statusnot on this map

MRI Sequence and Imaging Protocol Development

TypeobservationalSponsorNational Heart Centre SingaporeRan2016 to 2022Enrolled200ConditionsCardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated, Left Ventricular Hypertrophy, Ischemic Heart DiseaseArmsCardiovascular Magnetic Resonance
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Exercise cardiac magnetic resonance imaging: a feasibility study and meta-analysis.American journal of physiology. Regulatory, integrative and comparative physiology · 2018
    Pooled it
  2. Multiparametric exercise stress cardiovascular magnetic resonance in the diagnosis of coronary artery disease: the EMPIRE trial.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
    Trial
  3. Article
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  6. Accelerated real-time cine and flow under in-magnet staged exercise.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Article
  7. Article
  8. The future of CMR: All-in-one vs. real-time CMR (Part 2).Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. An inline deep learning based free-breathing ECG-free cine for exercise cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thu-Thao LeNational Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. le.thu.thao@nhcs.com.sg.
Jennifer Ann BryantNational Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.
Alicia Er TingNational Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.
Pei Yi HoNational Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.
Boyang SuNational Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.
Raymond Choon Chye TeoChangi General Hospital, Singapore, Singapore.
Julian Siong-Jin GanSiemens Healthineers, Erlangen, Germany.
Yiu-Cho ChungSiemens Healthineers, Erlangen, Germany.
Declan P O'ReganMRC London Institute of Medical Sciences, London, UK.
Stuart A CookNational Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.
Calvin Woon-Loong ChinNational Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise cardiovascular magnetic resonance (ExCMR) has great potential for clinical use but its development has been limited by a lack of compatible equipment and robust real-time imaging techniques. We developed an exCMR protocol using an in-scanner cycle ergometer and assessed its performance in differentiating athletes from non-athletes.

methodsFree-breathing real-time CMR (1.5T Aera, Siemens) was performed in 11 athletes (5 males; median age 29 [IQR: 28-39] years) and 16 age- and sex-matched healthy volunteers (7 males; median age 26 [interquartile range (IQR): 25-33] years). All participants underwent an in-scanner exercise protocol on a CMR compatible cycle ergometer (Lode BV, the Netherlands), with an initial workload of 25W followed by 25W-increment every minute. In 20 individuals, exercise capacity was also evaluated by cardiopulmonary exercise test (CPET). Scan-rescan reproducibility was assessed in 10 individuals, at least 7 days apart.

resultsThe exCMR protocol demonstrated excellent scan-rescan (cardiac index (CI): 0.2 ± 0.5L/min/m

conclusionsWe have developed a novel in-scanner exCMR protocol using real-time CMR that is highly reproducible. It may now be developed for clinical use for physiological studies of the heart and circulation.

Indexed as

AthletesCardiorespiratory FitnessExercise TestMagnetic Resonance ImagingPhysical EnduranceVentricular Function, LeftAdultBicyclingBlood PressureCardiac OutputCase-Control StudiesExercise ToleranceFeasibility StudiesFemaleHeartHeart RateCardiopulmonary exercise testCardiovascular magnetic resonanceExercise physiologySupine bike ergometer

Identifiers

PMID28110638
PMCPMC5256575

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.