Observational studyAmerican journal of Alzheimer's disease and other dementias2017
A Path Analysis of Dependence and Quality of Life in Alzheimer's Disease.
Observational study in American journal of Alzheimer's disease and other dementias, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Convergent validity of EQ-5D with core outcomes in dementia: a systematic review.Health and quality of life outcomes · 2022Pooled it
- The effect of paracetamol on care dependency and daily functioning in persons with advanced dementia living in long-term care facilities.BMC geriatrics · 2024Trial
- Dietary intakes and biomarker patterns of folate, vitamin BClinical epigenetics · 2019Trial
- Quality of Life in Mild Cognitive Impairment and Mild Dementia Associated with Alzheimer's Disease: A Systematic Review.Neurology and therapy · 2025Review
- The relationship between dementia staging scales, cognitive-behavioral scales and functionality in patients with cognitive impairment.PloS one · 2025Article
- Health-related physical indicators and self-rated quality of life in older adults with neurocognitive disorder.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Prospective memory partially mediates the association between aging and everyday functioning.The Clinical neuropsychologist · 2020Article
- Operationalizing and evaluating the Frascati criteria for functional decline in diagnosing HIV-associated neurocognitive disorders in adults.Journal of neurovirology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the direct and indirect relationships of cognitive, functional, and behavioral factors and other medical comorbidities with the quality of life (QoL) of patients with Alzheimer's disease (AD) according to the theoretical model of dependence.
methodsObservational and cross-sectional study. Cognitive and functional status, behavior, dependence, medical comorbidities, and QoL were assessed by using standardized instruments. A path analysis was used to model the direct and indirect relationships among clinical indicators according to the theoretically based model of dependence.
resultsThe sample consisted of 343 patients with AD (32.1% mild, 36.7% moderate, and 31.2% severe). Medical comorbidities, disease severity, and dependence level had a direct relationship with QoL. The functional disability and the behavior disturbances were indirectly related to QoL via dependence level, and the cognitive impairment was indirectly related to QoL via severity level.
conclusionDirect and indirect effects exist between clinical indicators, dependence, and QoL.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.