Evidence map›Paper›PMID 28110473›Full record

ArticleAIDS and behavior2018

How Presentation of Drug Detection Results Changed Reports of Product Adherence in South Africa, Uganda and Zimbabwe.

Petina Musara, Elizabeth T Montgomery, Nyaradzo M Mgodi, Kubashni Woeber, Carolyne A Akello, Miriam Hartmann, Helen Cheng, Lisa Levy, Ariana Katz, Cynthia I Grossman and 4 more

Abstract read
In one paragraph

Article in AIDS and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Petina MusaraUniversity of Zimbabwe-University of California San Francisco Collaborative Research Programme, 15 Phillips, Belgravia, Harare, Zimbabwe. petina@uz-ucsf.co.zw.ORCID 0000-0001-9668-4344
Elizabeth T MontgomeryWomen's Global Health Imperative; RTI International, San Francisco, CA, USA.
Nyaradzo M MgodiUniversity of Zimbabwe-University of California San Francisco Collaborative Research Programme, 15 Phillips, Belgravia, Harare, Zimbabwe.
Kubashni WoeberHIV Prevention Research Unit, South African Medical Research Council, Cape Town, South Africa.
Carolyne A AkelloMakerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.
Miriam HartmannWomen's Global Health Imperative; RTI International, San Francisco, CA, USA.
Helen ChengWomen's Global Health Imperative; RTI International, San Francisco, CA, USA.
Lisa LevyFHI-360, Durham, NC, USA.
Ariana KatzWomen's Global Health Imperative; RTI International, San Francisco, CA, USA.
Cynthia I GrossmanDAIDS/NIH/NIMH, Bethesda, MD, USA.
Z Mike ChirenjeUniversity of Zimbabwe-University of California San Francisco Collaborative Research Programme, 15 Phillips, Belgravia, Harare, Zimbabwe.
Ariane van der StratenWomen's Global Health Imperative; RTI International, San Francisco, CA, USA.
Barbara MenschPopulation Council, New York, NY, USA.
Microbicide Trials Network-003D Study Team

Funding

Microbicide Trials NetworkUM1AI068633 · NIAID · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI HILLIER, SHARON L. · 2011 to 2021
$175.0M
UZ-UCSF CTUUM1AI069436 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZVAVAHERA MIKE CHIRENJE, LYNDA STRANIX-CHIBANDA · 2012 to 2026
$75.9M
Statistical and Data Management Center (SDMC): Microbicide Trials NetworkUM1AI068615 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BROWN, ELIZABETH RENATA · 2011 to 2021
$66.5M
Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
UZ-UCSF Clinical Trials UnitU01AI069436 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIRENJE, ZVAVAHERA MIKE · 2007 to 2011
$49.3M
Laboratory Center (LC): Microbicide Trials NetworkUM1AI106707 · NIAID · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI MELLORS, JOHN W, ROHAN, LISA CENCIA · 2014 to 2021
$27.1M
NIAID NIH HHS U01 AI069436NIAID NIH HHS UM1 AI068615NIAID NIH HHS UM1 AI068633NIAID NIH HHS UM1 AI069436NIAID NIH HHS UM1 AI106707NIMH NIH HHS P30 MH062246
6 · The paper itself

Abstract

Accurate estimates of study product use are critical to understanding and addressing adherence challenges in HIV prevention trials. The VOICE trial exposed a significant gap between self-reported adherence and drug detection. The VOICE-D qualitative study was designed to better understand non-adherence during VOICE, and was conducted in 2 stages: before (stage 1) and after (stage 2) drug detection results were provided to participants. Transcripts from 44 women who participated in both stages were analysed to understand the effect of presenting drug detection data on narratives of product use. Thirty-six women reported high adherence in stage 1, yet admitted non-use in stage 2, three reported high adherence in both stages (contrary to their drug detection results) and five had consistent responses across both stages and drug results. Presenting objective measures of use may facilitate more accurate product use reporting and should be evaluated in future prevention trials.

Indexed as

Medication AdherencePre-Exposure ProphylaxisAdultAnti-HIV AgentsFemaleHIV InfectionsHumansQualitative ResearchSelf ReportSouth AfricaUgandaZimbabweAnti-HIV AgentsAdherence measuresDrug detection resultsHIV preventionMicrobicidesPre-exposure prophylaxis

Identifiers

PMID28110473
PMCPMC5587392

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.